Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

Adel S. Girgis; Siva S. Panda; Peter J. Steel

doi:10.1039/c4ra13433h

Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

Adel S. Girgis, Siva S. Panda, Peter J. Steel

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P2₁/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.

Original language	English (US)
Pages (from-to)	14780-14787
Number of pages	8
Journal	RSC Advances
Volume	5
Issue number	19
DOIs	https://doi.org/10.1039/c4ra13433h
State	Published - 2015
Externally published	Yes

ASJC Scopus subject areas

General Chemical Engineering
General Chemistry

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title = "Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole",

abstract = "Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P21/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.",

author = "Girgis, {Adel S.} and Panda, {Siva S.} and Steel, {Peter J.}",

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AU - Panda, Siva S.

AU - Steel, Peter J.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015

Y1 - 2015

N2 - Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P21/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.

AB - Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P21/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.

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Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

Abstract

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