Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

Adel S. Girgis, Siva S. Panda, Peter J. Steel

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P21/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.

Original languageEnglish (US)
Pages (from-to)14780-14787
Number of pages8
JournalRSC Advances
Volume5
Issue number19
DOIs
StatePublished - 2015
Externally publishedYes

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Discrete Fourier transforms
Cells
Single crystals
X rays
Molecules
oxindole

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole. / Girgis, Adel S.; Panda, Siva S.; Steel, Peter J.

In: RSC Advances, Vol. 5, No. 19, 2015, p. 14780-14787.

Research output: Contribution to journalArticle

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