Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke

Nelson E. Lezcano, Nadine Odo, Abdullah Kutlar, Donald Brambilla, Robert J. Adams

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Intravascular hemolysis releases large amounts of free hemoglobin (PFH) in plasma of sickle- cell disease (SCD) patients. PFH has been associated with harmful endothelial actions including scavenging nitric oxide (NO). Whether PFH plays a role in stroke in SCD has not been examined. METHODS - Serum levels of PFH, lactate dehydrogenase, and total bilirubin were measured in stored sera from children at risk for stroke treated in a randomized controlled trial of regular red cell transfusion (STOP study). Baseline and post-treatment (≈1 year of transfusion) were compared to determine whether treatment (which reduces stroke risk by 90%) was associated with reduction in markers of hemolysis. RESULTS - Baseline serum PFH values did not differ between treatment groups. PFH declined with repeated transfusion from 78.7±8.2 mg/dL to 34.4±3.4 mg/dL (P<0.001). With only episodic or no transfusion the drop was smaller: 80.9±7.5 to 62.8±5.0 (P=0.019). The decrease was larger in those with regular transfusion (56% versus 22%; P<0.001). Reduction of lactate dehydrogenase and total bilirubin was observed only in those on regular transfusion. CONCLUSIONS - Regular transfusion which lowers stroke risk is associated with a significant reduction in PFH. A role for PFH in promoting stroke in SCD should be investigated.

Original languageEnglish (US)
Pages (from-to)1424-1426
Number of pages3
JournalStroke
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2006

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Sickle Cell Anemia
Hemoglobins
Stroke
Hemolysis
L-Lactate Dehydrogenase
Bilirubin
Serum
Plasma Cells
Nitric Oxide
Therapeutics
Randomized Controlled Trials

Keywords

  • Children
  • Hemolysis
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke. / Lezcano, Nelson E.; Odo, Nadine; Kutlar, Abdullah; Brambilla, Donald; Adams, Robert J.

In: Stroke, Vol. 37, No. 6, 01.06.2006, p. 1424-1426.

Research output: Contribution to journalArticle

Lezcano, Nelson E. ; Odo, Nadine ; Kutlar, Abdullah ; Brambilla, Donald ; Adams, Robert J. / Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke. In: Stroke. 2006 ; Vol. 37, No. 6. pp. 1424-1426.
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