Regulation and pathological role of p53 in cisplatin nephrotoxicity

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. However, its use is limited by side effects in normal tissues, particularly the kidneys. Recent studies, using both in vitro and in vivo experimental models, have suggested a critical role for p53 in cisplatin nephrotoxicity. The signaling pathways upstream and downstream of p53 are being investigated and related to renal cell injury and death. Along with the mechanistic studies, renoprotective approaches targeting p53 have been suggested. Further research may integrate p53 signaling with other nephrotoxic signaling pathways, providing a comprehensive understanding of cisplatin nephrotoxicity and leading to the development of effective renoprotective strategies during cancer therapy.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume327
Issue number2
DOIs
StatePublished - Nov 1 2008

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Cisplatin
Kidney
Neoplasms
Cell Death
Theoretical Models
Drug Therapy
Wounds and Injuries
Therapeutics
Research
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Regulation and pathological role of p53 in cisplatin nephrotoxicity. / Livingston, Man Jiang; Dong, Zheng.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 327, No. 2, 01.11.2008, p. 300-307.

Research output: Contribution to journalReview article

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