Regulation of α2B-adrenerigc receptor export trafficking by specific motifs

Guangyu Wu, Jason E. Davis, Maoxiang Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Intracellular trafficking and precise targeting to specific locations of G protein-coupled receptors (GPCRs) control the physiological functions of the receptors. Compared to the extensive efforts dedicated to understanding the events involved in the endocytic and recycling pathways, the molecular mechanisms underlying the transport of the GPCR superfamily from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane are relatively less well defined. Over the past years, we have used α2B-adrenergic receptor (α2B-AR) as a model to define the factors that control GPCR export trafficking. In this chapter, we will review specific motifs identified to mediate the export of nascent α2B-AR from the ER and the Golgi and discuss the possible underlying mechanisms. As these motifs are highly conserved among GPCRs, they may provide common mechanisms for export trafficking of these receptors.

Original languageEnglish (US)
Title of host publicationTrafficking of GPCRs, 2015
EditorsGuangyu Wu
PublisherElsevier B.V.
Pages227-244
Number of pages18
ISBN (Print)9780128029398
DOIs
StatePublished - 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume132
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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    Wu, G., Davis, J. E., & Zhang, M. (2015). Regulation of α2B-adrenerigc receptor export trafficking by specific motifs. In G. Wu (Ed.), Trafficking of GPCRs, 2015 (pp. 227-244). (Progress in Molecular Biology and Translational Science; Vol. 132). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2015.03.004