Regulation of α2B-adrenerigc receptor export trafficking by specific motifs

Guangyu Wu, Jason E. Davis, Maoxiang Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Intracellular trafficking and precise targeting to specific locations of G protein-coupled receptors (GPCRs) control the physiological functions of the receptors. Compared to the extensive efforts dedicated to understanding the events involved in the endocytic and recycling pathways, the molecular mechanisms underlying the transport of the GPCR superfamily from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane are relatively less well defined. Over the past years, we have used α2B-adrenergic receptor (α2B-AR) as a model to define the factors that control GPCR export trafficking. In this chapter, we will review specific motifs identified to mediate the export of nascent α2B-AR from the ER and the Golgi and discuss the possible underlying mechanisms. As these motifs are highly conserved among GPCRs, they may provide common mechanisms for export trafficking of these receptors.

Original languageEnglish (US)
Title of host publicationTrafficking of GPCRs, 2015
EditorsGuangyu Wu
PublisherElsevier B.V.
Pages227-244
Number of pages18
ISBN (Print)9780128029398
DOIs
StatePublished - Jan 1 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume132
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Fingerprint

G-Protein-Coupled Receptors
Endoplasmic Reticulum
Adrenergic Receptors
Carrier Proteins
Cell Membrane

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Wu, G., Davis, J. E., & Zhang, M. (2015). Regulation of α2B-adrenerigc receptor export trafficking by specific motifs. In G. Wu (Ed.), Trafficking of GPCRs, 2015 (pp. 227-244). (Progress in Molecular Biology and Translational Science; Vol. 132). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2015.03.004

Regulation of α2B-adrenerigc receptor export trafficking by specific motifs. / Wu, Guangyu; Davis, Jason E.; Zhang, Maoxiang.

Trafficking of GPCRs, 2015. ed. / Guangyu Wu. Elsevier B.V., 2015. p. 227-244 (Progress in Molecular Biology and Translational Science; Vol. 132).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wu, G, Davis, JE & Zhang, M 2015, Regulation of α2B-adrenerigc receptor export trafficking by specific motifs. in G Wu (ed.), Trafficking of GPCRs, 2015. Progress in Molecular Biology and Translational Science, vol. 132, Elsevier B.V., pp. 227-244. https://doi.org/10.1016/bs.pmbts.2015.03.004
Wu G, Davis JE, Zhang M. Regulation of α2B-adrenerigc receptor export trafficking by specific motifs. In Wu G, editor, Trafficking of GPCRs, 2015. Elsevier B.V. 2015. p. 227-244. (Progress in Molecular Biology and Translational Science). https://doi.org/10.1016/bs.pmbts.2015.03.004
Wu, Guangyu ; Davis, Jason E. ; Zhang, Maoxiang. / Regulation of α2B-adrenerigc receptor export trafficking by specific motifs. Trafficking of GPCRs, 2015. editor / Guangyu Wu. Elsevier B.V., 2015. pp. 227-244 (Progress in Molecular Biology and Translational Science).
@inproceedings{65ae06fa4dbb4c61a77a64e0183ae30f,
title = "Regulation of α2B-adrenerigc receptor export trafficking by specific motifs",
abstract = "Intracellular trafficking and precise targeting to specific locations of G protein-coupled receptors (GPCRs) control the physiological functions of the receptors. Compared to the extensive efforts dedicated to understanding the events involved in the endocytic and recycling pathways, the molecular mechanisms underlying the transport of the GPCR superfamily from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane are relatively less well defined. Over the past years, we have used α2B-adrenergic receptor (α2B-AR) as a model to define the factors that control GPCR export trafficking. In this chapter, we will review specific motifs identified to mediate the export of nascent α2B-AR from the ER and the Golgi and discuss the possible underlying mechanisms. As these motifs are highly conserved among GPCRs, they may provide common mechanisms for export trafficking of these receptors.",
author = "Guangyu Wu and Davis, {Jason E.} and Maoxiang Zhang",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/bs.pmbts.2015.03.004",
language = "English (US)",
isbn = "9780128029398",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "227--244",
editor = "Guangyu Wu",
booktitle = "Trafficking of GPCRs, 2015",

}

TY - GEN

T1 - Regulation of α2B-adrenerigc receptor export trafficking by specific motifs

AU - Wu, Guangyu

AU - Davis, Jason E.

AU - Zhang, Maoxiang

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Intracellular trafficking and precise targeting to specific locations of G protein-coupled receptors (GPCRs) control the physiological functions of the receptors. Compared to the extensive efforts dedicated to understanding the events involved in the endocytic and recycling pathways, the molecular mechanisms underlying the transport of the GPCR superfamily from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane are relatively less well defined. Over the past years, we have used α2B-adrenergic receptor (α2B-AR) as a model to define the factors that control GPCR export trafficking. In this chapter, we will review specific motifs identified to mediate the export of nascent α2B-AR from the ER and the Golgi and discuss the possible underlying mechanisms. As these motifs are highly conserved among GPCRs, they may provide common mechanisms for export trafficking of these receptors.

AB - Intracellular trafficking and precise targeting to specific locations of G protein-coupled receptors (GPCRs) control the physiological functions of the receptors. Compared to the extensive efforts dedicated to understanding the events involved in the endocytic and recycling pathways, the molecular mechanisms underlying the transport of the GPCR superfamily from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane are relatively less well defined. Over the past years, we have used α2B-adrenergic receptor (α2B-AR) as a model to define the factors that control GPCR export trafficking. In this chapter, we will review specific motifs identified to mediate the export of nascent α2B-AR from the ER and the Golgi and discuss the possible underlying mechanisms. As these motifs are highly conserved among GPCRs, they may provide common mechanisms for export trafficking of these receptors.

UR - http://www.scopus.com/inward/record.url?scp=84942190717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942190717&partnerID=8YFLogxK

U2 - 10.1016/bs.pmbts.2015.03.004

DO - 10.1016/bs.pmbts.2015.03.004

M3 - Conference contribution

C2 - 26055061

AN - SCOPUS:84942190717

SN - 9780128029398

T3 - Progress in Molecular Biology and Translational Science

SP - 227

EP - 244

BT - Trafficking of GPCRs, 2015

A2 - Wu, Guangyu

PB - Elsevier B.V.

ER -