TY - JOUR
T1 - Regulation of metastasis by microRNAs in ovarian cancer
AU - Wang, Yongchao
AU - Kim, Sangmi
AU - Kim, Il-man
PY - 2014
Y1 - 2014
N2 - Ovarian cancer (OC) is the second most common and the most fatal gynecologic cancer in the United States. Over the last decade, various targeted therapeutics have been introduced but there has been no corresponding improvement in patient survival mainly because of the lack of effective early detection methods. microRNAs (miRs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Accumulating data suggest central regulatory roles of miRs in modulating OC initiation, progression, and metastasis. More recently, aberrant miR expression has been also associated with cancer stem cell (CSC) phenotypes and development of CSC chemo-resistance. Here, we review recent advances on miRs and OC metastasis and discuss the concept that miRs are involved in both CSC transformation and subsequent OC metastasis. Finally, we describe the prevalence of circulating miRs and assess their potential utilities as biomarkers for OC diagnosis, prognosis, and therapeutics.
AB - Ovarian cancer (OC) is the second most common and the most fatal gynecologic cancer in the United States. Over the last decade, various targeted therapeutics have been introduced but there has been no corresponding improvement in patient survival mainly because of the lack of effective early detection methods. microRNAs (miRs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Accumulating data suggest central regulatory roles of miRs in modulating OC initiation, progression, and metastasis. More recently, aberrant miR expression has been also associated with cancer stem cell (CSC) phenotypes and development of CSC chemo-resistance. Here, we review recent advances on miRs and OC metastasis and discuss the concept that miRs are involved in both CSC transformation and subsequent OC metastasis. Finally, we describe the prevalence of circulating miRs and assess their potential utilities as biomarkers for OC diagnosis, prognosis, and therapeutics.
KW - Angiogenesis
KW - Cancer stem cells
KW - Epithelial-mesenchymal transition
KW - Extracellular matrix
KW - Ovarian cancer
KW - miRs
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U2 - 10.3389/fonc.2014.00143
DO - 10.3389/fonc.2014.00143
M3 - Short survey
AN - SCOPUS:84904612549
SN - 2234-943X
VL - 4 JUN
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 143
ER -