TY - JOUR
T1 - Regulation of mitochondria function by natriuretic peptides
AU - Domondon, Mark
AU - Nikiforova, Anna B.
AU - DeLeon-Pennell, Kristine Y.
AU - Ilatovskaya, Daria V.
N1 - Publisher Copyright:
© 2019 American Physiological Society. All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - Natriuretic peptides (NPs) are well known to promote renal Na+ excretion, counteracting the effects of the renin-angiotensinaldosterone system. Thus, NPs serve as a key component in the maintenance of blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis and enhance lipid oxidation and mitochondrial respiration. Here, we provide an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, Ca2+ signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed at understanding and potentially using it as a therapeutic target from a completely new angle.
AB - Natriuretic peptides (NPs) are well known to promote renal Na+ excretion, counteracting the effects of the renin-angiotensinaldosterone system. Thus, NPs serve as a key component in the maintenance of blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis and enhance lipid oxidation and mitochondrial respiration. Here, we provide an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, Ca2+ signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed at understanding and potentially using it as a therapeutic target from a completely new angle.
KW - Atrial natriuretic peptide
KW - CGMP
KW - Guanylate cyclase
KW - Mitochondria
KW - Natriuretic peptides
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U2 - 10.1152/ajprenal.00384.2019
DO - 10.1152/ajprenal.00384.2019
M3 - Review article
C2 - 31509010
AN - SCOPUS:85074185094
SN - 1931-857X
VL - 317
SP - F1164-F1168
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
IS - 5
ER -