Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues

B. Paul Herring, Omar El-Mounayri, Patricia J. Gallagher, Feng Yin, Jiliang Zhou

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

The mylk1 gene is a large gene spanning ∼250 kb and comprising at least 31 exons. The mylk1 gene encodes at least four protein products: two isoforms of the 220-kDa myosin light chain kinase (MLCK), a 130-kDa MLCK, and telokin. Transcripts encoding these products are derived from four independent promoters within the mylk1 gene. The kinases expressed from the mylk1 gene have been extensively characterized and function to regulate the activity of nonmuscle and smooth muscle myosin II. Activation of these myosin motors by MLCK modulates a variety of contractile processes, including smooth muscle contraction, cell adhesion, migration, and proliferation. Dysregulation of these processes contributes to a number of diseases. The noncatalytic gene product telokin also has been shown to modulate contraction in smooth muscle cells through its ability to inhibit myosin light chain phosphatase. Given the crucial role of the products of the mylk1 gene in regulating numerous contractile processes, it seems intuitive that alterations in the transcriptional activity of the mylk1 gene also will have a significant impact on many physiological and pathological processes. In this review we highlight some of the recent studies that have described the transcriptional regulation of mylk1 gene products in smooth muscle tissues and discuss the implications of these findings for regulation of expression of other smooth muscle-specific genes.

Original languageEnglish (US)
Pages (from-to)C817-C827
JournalAmerican Journal of Physiology - Cell Physiology
Volume291
Issue number5
DOIs
StatePublished - Nov 24 2006

Fingerprint

Myosin-Light-Chain Kinase
Smooth Muscle
Muscle
Genes
Tissue
Muscles
Smooth Muscle Myocytes
Myosin-Light-Chain Phosphatase
telokin
Physiological Phenomena
Smooth Muscle Myosins
Myosin Type II
Cell adhesion
Pathologic Processes
Myosins
Muscle Contraction
Cell Adhesion
Cell Movement
Exons
Protein Isoforms

Keywords

  • GATA
  • Gene expression
  • Hox genes
  • Myocardin
  • Serum response factor

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues. / Herring, B. Paul; El-Mounayri, Omar; Gallagher, Patricia J.; Yin, Feng; Zhou, Jiliang.

In: American Journal of Physiology - Cell Physiology, Vol. 291, No. 5, 24.11.2006, p. C817-C827.

Research output: Contribution to journalReview article

Herring, B. Paul ; El-Mounayri, Omar ; Gallagher, Patricia J. ; Yin, Feng ; Zhou, Jiliang. / Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues. In: American Journal of Physiology - Cell Physiology. 2006 ; Vol. 291, No. 5. pp. C817-C827.
@article{af166d748f8f4efd9770b565f8afd96f,
title = "Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues",
abstract = "The mylk1 gene is a large gene spanning ∼250 kb and comprising at least 31 exons. The mylk1 gene encodes at least four protein products: two isoforms of the 220-kDa myosin light chain kinase (MLCK), a 130-kDa MLCK, and telokin. Transcripts encoding these products are derived from four independent promoters within the mylk1 gene. The kinases expressed from the mylk1 gene have been extensively characterized and function to regulate the activity of nonmuscle and smooth muscle myosin II. Activation of these myosin motors by MLCK modulates a variety of contractile processes, including smooth muscle contraction, cell adhesion, migration, and proliferation. Dysregulation of these processes contributes to a number of diseases. The noncatalytic gene product telokin also has been shown to modulate contraction in smooth muscle cells through its ability to inhibit myosin light chain phosphatase. Given the crucial role of the products of the mylk1 gene in regulating numerous contractile processes, it seems intuitive that alterations in the transcriptional activity of the mylk1 gene also will have a significant impact on many physiological and pathological processes. In this review we highlight some of the recent studies that have described the transcriptional regulation of mylk1 gene products in smooth muscle tissues and discuss the implications of these findings for regulation of expression of other smooth muscle-specific genes.",
keywords = "GATA, Gene expression, Hox genes, Myocardin, Serum response factor",
author = "Herring, {B. Paul} and Omar El-Mounayri and Gallagher, {Patricia J.} and Feng Yin and Jiliang Zhou",
year = "2006",
month = "11",
day = "24",
doi = "10.1152/ajpcell.00198.2006",
language = "English (US)",
volume = "291",
pages = "C817--C827",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues

AU - Herring, B. Paul

AU - El-Mounayri, Omar

AU - Gallagher, Patricia J.

AU - Yin, Feng

AU - Zhou, Jiliang

PY - 2006/11/24

Y1 - 2006/11/24

N2 - The mylk1 gene is a large gene spanning ∼250 kb and comprising at least 31 exons. The mylk1 gene encodes at least four protein products: two isoforms of the 220-kDa myosin light chain kinase (MLCK), a 130-kDa MLCK, and telokin. Transcripts encoding these products are derived from four independent promoters within the mylk1 gene. The kinases expressed from the mylk1 gene have been extensively characterized and function to regulate the activity of nonmuscle and smooth muscle myosin II. Activation of these myosin motors by MLCK modulates a variety of contractile processes, including smooth muscle contraction, cell adhesion, migration, and proliferation. Dysregulation of these processes contributes to a number of diseases. The noncatalytic gene product telokin also has been shown to modulate contraction in smooth muscle cells through its ability to inhibit myosin light chain phosphatase. Given the crucial role of the products of the mylk1 gene in regulating numerous contractile processes, it seems intuitive that alterations in the transcriptional activity of the mylk1 gene also will have a significant impact on many physiological and pathological processes. In this review we highlight some of the recent studies that have described the transcriptional regulation of mylk1 gene products in smooth muscle tissues and discuss the implications of these findings for regulation of expression of other smooth muscle-specific genes.

AB - The mylk1 gene is a large gene spanning ∼250 kb and comprising at least 31 exons. The mylk1 gene encodes at least four protein products: two isoforms of the 220-kDa myosin light chain kinase (MLCK), a 130-kDa MLCK, and telokin. Transcripts encoding these products are derived from four independent promoters within the mylk1 gene. The kinases expressed from the mylk1 gene have been extensively characterized and function to regulate the activity of nonmuscle and smooth muscle myosin II. Activation of these myosin motors by MLCK modulates a variety of contractile processes, including smooth muscle contraction, cell adhesion, migration, and proliferation. Dysregulation of these processes contributes to a number of diseases. The noncatalytic gene product telokin also has been shown to modulate contraction in smooth muscle cells through its ability to inhibit myosin light chain phosphatase. Given the crucial role of the products of the mylk1 gene in regulating numerous contractile processes, it seems intuitive that alterations in the transcriptional activity of the mylk1 gene also will have a significant impact on many physiological and pathological processes. In this review we highlight some of the recent studies that have described the transcriptional regulation of mylk1 gene products in smooth muscle tissues and discuss the implications of these findings for regulation of expression of other smooth muscle-specific genes.

KW - GATA

KW - Gene expression

KW - Hox genes

KW - Myocardin

KW - Serum response factor

UR - http://www.scopus.com/inward/record.url?scp=33751174504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751174504&partnerID=8YFLogxK

U2 - 10.1152/ajpcell.00198.2006

DO - 10.1152/ajpcell.00198.2006

M3 - Review article

C2 - 16774989

AN - SCOPUS:33751174504

VL - 291

SP - C817-C827

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 5

ER -