Abstract
Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules of ErbB4, suggesting that PSD-95 facilitates ErbB4 dimerization. Finally, NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission. Thus, NRG signaling may be synaptic and regulated by PSD-95. A role of NRG signaling in the adult CNS may be modulation of synaptic plasticity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 443-455 |
| Number of pages | 13 |
| Journal | Neuron |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2000 |
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- Neuroscience(all)
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Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. / Huang, Yang Z.; Won, Sandra; Ali, Declan W.; Wang, Qiang; Tanowitz, Michael; Du, Quansheng; Pelkey, Kenneth A.; Yang, Da J.; Xiong, Wencheng; Salter, Michael W.; Mei, Lin.
In: Neuron, Vol. 26, No. 2, 01.01.2000, p. 443-455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses
AU - Huang, Yang Z.
AU - Won, Sandra
AU - Ali, Declan W.
AU - Wang, Qiang
AU - Tanowitz, Michael
AU - Du, Quansheng
AU - Pelkey, Kenneth A.
AU - Yang, Da J.
AU - Xiong, Wencheng
AU - Salter, Michael W.
AU - Mei, Lin
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules of ErbB4, suggesting that PSD-95 facilitates ErbB4 dimerization. Finally, NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission. Thus, NRG signaling may be synaptic and regulated by PSD-95. A role of NRG signaling in the adult CNS may be modulation of synaptic plasticity.
AB - Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules of ErbB4, suggesting that PSD-95 facilitates ErbB4 dimerization. Finally, NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission. Thus, NRG signaling may be synaptic and regulated by PSD-95. A role of NRG signaling in the adult CNS may be modulation of synaptic plasticity.
UR - http://www.scopus.com/inward/record.url?scp=0033697710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033697710&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(00)81176-9
DO - 10.1016/S0896-6273(00)81176-9
M3 - Article
C2 - 10839362
AN - SCOPUS:0033697710
VL - 26
SP - 443
EP - 455
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 2
ER -