Regulation of post-Golgi traffic of G protein-coupled receptors.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Anterograde trafficking of newly synthesized G protein-coupled -receptors (GPCRs) from the endoplasmic reticulum to the cell surface represents a crucial checkpoint in controlling the amount of the functional receptors at the cell surface and the strength of signaling initiated by the receptors. In contrast to the extensively studied, well-understood endocytic and recycling pathways, the molecular mechanisms underlying the cell-surface targeting of the receptors remain poorly defined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on specific motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
JournalSub-Cellular Biochemistry
Volume63
StatePublished - Jan 1 2012

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G-Protein-Coupled Receptors
Cell Surface Receptors
Cell membranes
Sorting
Endoplasmic Reticulum
Recycling
Blood Proteins
Carrier Proteins
Membrane Proteins
Cell Membrane

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Cite this

Regulation of post-Golgi traffic of G protein-coupled receptors. / Wu, Guangyu.

In: Sub-Cellular Biochemistry, Vol. 63, 01.01.2012, p. 83-95.

Research output: Contribution to journalReview article

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