Abstract
The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | L832-L845 |
| Journal | American Journal of Physiology - Lung Cellular and Molecular Physiology |
| Volume | 311 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2016 |
Keywords
- Barrier function
- Endothelium
- Kinases
- Lung
- Permeability
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
- Physiology (medical)
- Cell Biology
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Cite this
Barabutis, N., Verin, A. D., & Catravas, J. D. (2016). Regulation of pulmonary endothelial barrier function by kinases. American Journal of Physiology - Lung Cellular and Molecular Physiology, 311(5), L832-L845. https://doi.org/10.1152/ajplung.00233.2016