Regulation of pulmonary endothelial barrier function by kinases

Nektarios Barabutis; Alexander Dmitriyevich Verin; John D. Catravas

doi:10.1152/ajplung.00233.2016

Regulation of pulmonary endothelial barrier function by kinases

Nektarios Barabutis, Alexander Dmitriyevich Verin, John D. Catravas

Pulmonary

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

Original language	English (US)
Pages (from-to)	L832-L845
Journal	American Journal of Physiology - Lung Cellular and Molecular Physiology
Volume	311
Issue number	5
DOIs	https://doi.org/10.1152/ajplung.00233.2016
State	Published - 2016

Keywords

Barrier function
Endothelium
Kinases
Lung
Permeability

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Physiology (medical)
Cell Biology

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10.1152/ajplung.00233.2016

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title = "Regulation of pulmonary endothelial barrier function by kinases",

abstract = "The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.",

keywords = "Barrier function, Endothelium, Kinases, Lung, Permeability",

author = "Nektarios Barabutis and Verin, {Alexander Dmitriyevich} and Catravas, {John D.}",

note = "Funding Information: This research was supported by National Heart, Lung, and Blood Institute Grant HL-101902. Publisher Copyright: {\textcopyright} 2016 the American Physiological Society.",

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AU - Barabutis, Nektarios

AU - Verin, Alexander Dmitriyevich

AU - Catravas, John D.

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N2 - The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

AB - The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

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KW - Endothelium

KW - Kinases

KW - Lung

KW - Permeability

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Regulation of pulmonary endothelial barrier function by kinases

Abstract

Keywords

ASJC Scopus subject areas

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