Regulation of pulmonary endothelial barrier function by kinases

Nektarios Barabutis, Alexander Dmitriyevich Verin, John D. Catravas

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

Original languageEnglish (US)
Pages (from-to)L832-L845
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume311
Issue number5
DOIs
StatePublished - Jan 1 2016

    Fingerprint

Keywords

  • Barrier function
  • Endothelium
  • Kinases
  • Lung
  • Permeability

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

Cite this