Abstract
The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | L832-L845 |
| Journal | American Journal of Physiology - Lung Cellular and Molecular Physiology |
| Volume | 311 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Barrier function
- Endothelium
- Kinases
- Lung
- Permeability
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
- Physiology (medical)
- Cell Biology
Cite this
Regulation of pulmonary endothelial barrier function by kinases. / Barabutis, Nektarios; Verin, Alexander Dmitriyevich; Catravas, John D.
In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 311, No. 5, 01.01.2016, p. L832-L845.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Regulation of pulmonary endothelial barrier function by kinases
AU - Barabutis, Nektarios
AU - Verin, Alexander Dmitriyevich
AU - Catravas, John D.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.
AB - The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.
KW - Barrier function
KW - Endothelium
KW - Kinases
KW - Lung
KW - Permeability
UR - http://www.scopus.com/inward/record.url?scp=84994627151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994627151&partnerID=8YFLogxK
U2 - 10.1152/ajplung.00233.2016
DO - 10.1152/ajplung.00233.2016
M3 - Review article
C2 - 27663990
AN - SCOPUS:84994627151
VL - 311
SP - L832-L845
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 5
ER -