Regulation of spine formation by ErbB4 in PV-positive interneurons

Dongmin Yin, Xiang Dong Sun, Jonathan C. Bean, Thiri W. Lin, Anupama Sathyamurthy, Wencheng Xiong, Tian Ming Gao, Yongjun Chen, Lin Mei

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The trophic factor neuregulin 1 (Nrg1) and its receptor ErbB4 are schizophrenia candidate genes. NRG1-ErbB4 signaling was thought to regulate spine formation and function in a cell-autonomous manner. Yet, recent studies indicate that ErbB4 expression is largely restricted to GABAergic interneurons and is very low or absent in pyramidal cells. Here, we generated and characterized cell type-specific ErbB4 mutant and transgenic mice. Spine density and the number of excitatory synapses were unaltered by neither deletion nor overexpression of ErbB4 in pyramidal neurons. However, spine density and excitatory synapse number were reduced in PV-ErbB4-/- mice where ErbB4 was selectively ablated in parvalbumin-positive GABAergic interneurons. Concurrently, basal glutamate transmission was impaired in PV-ErbB4-/- mice, but not in mice where ErbB4 was deleted or overexpressed in pyramidal neurons. Our results demonstrate a role of ErbB4 in PV-positive interneurons for spine formation in excitatory neurons.

Original languageEnglish (US)
Pages (from-to)19295-19303
Number of pages9
JournalJournal of Neuroscience
Volume33
Issue number49
DOIs
StatePublished - Dec 9 2013

Fingerprint

Interneurons
Pyramidal Cells
Spine
Synapses
Neuregulin-1
Parvalbumins
Transgenic Mice
Glutamic Acid
Schizophrenia
Neurons
Genes

Keywords

  • ErbB4
  • GABAergic
  • Glutamatergic
  • Neuregulin
  • Schizophrenia
  • Spine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yin, D., Sun, X. D., Bean, J. C., Lin, T. W., Sathyamurthy, A., Xiong, W., ... Mei, L. (2013). Regulation of spine formation by ErbB4 in PV-positive interneurons. Journal of Neuroscience, 33(49), 19295-19303. https://doi.org/10.1523/JNEUROSCI.2090-13.2013

Regulation of spine formation by ErbB4 in PV-positive interneurons. / Yin, Dongmin; Sun, Xiang Dong; Bean, Jonathan C.; Lin, Thiri W.; Sathyamurthy, Anupama; Xiong, Wencheng; Gao, Tian Ming; Chen, Yongjun; Mei, Lin.

In: Journal of Neuroscience, Vol. 33, No. 49, 09.12.2013, p. 19295-19303.

Research output: Contribution to journalArticle

Yin, D, Sun, XD, Bean, JC, Lin, TW, Sathyamurthy, A, Xiong, W, Gao, TM, Chen, Y & Mei, L 2013, 'Regulation of spine formation by ErbB4 in PV-positive interneurons', Journal of Neuroscience, vol. 33, no. 49, pp. 19295-19303. https://doi.org/10.1523/JNEUROSCI.2090-13.2013
Yin D, Sun XD, Bean JC, Lin TW, Sathyamurthy A, Xiong W et al. Regulation of spine formation by ErbB4 in PV-positive interneurons. Journal of Neuroscience. 2013 Dec 9;33(49):19295-19303. https://doi.org/10.1523/JNEUROSCI.2090-13.2013
Yin, Dongmin ; Sun, Xiang Dong ; Bean, Jonathan C. ; Lin, Thiri W. ; Sathyamurthy, Anupama ; Xiong, Wencheng ; Gao, Tian Ming ; Chen, Yongjun ; Mei, Lin. / Regulation of spine formation by ErbB4 in PV-positive interneurons. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 49. pp. 19295-19303.
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