Regulation of the Trafficking and Function of G Protein-Coupled Receptors by Rab1 GTPase in Cardiomyocytes

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) play a crucial role in regulating cardiac growth and function under normal and diseased conditions. It has been well documented that the precise function of GPCRs is controlled by intracellular trafficking of the receptors. Compared with the extensive studies on the events of the endocytic pathway, molecular mechanism underlying the transport process of GPCRs from the endoplasmic reticulum (ER) through the Golgi to the cell surface and regulation of receptor signaling by these processes in cardiac myocytes remain poorly defined. This chapter describes the methods to characterize the function of Rab1 GTPase, which modulates protein transport from the ER to the Golgi apparatus, in the trafficking and signaling of angiotensin II type 1 receptor (AT1R), α1-adrenergic receptor (AR), and β-AR, and in hypertrophic growth in response to agonist stimulation in neonatal cardiac myocytes.

Original languageEnglish (US)
Title of host publicationSmall GTPases in Disease, Part A
EditorsWilliam Balch, Alan Hall, Channing Der
Pages227-238
Number of pages12
DOIs
StatePublished - Sep 24 2008
Externally publishedYes

Publication series

NameMethods in Enzymology
Volume438
ISSN (Print)0076-6879

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Wu, G. (2008). Regulation of the Trafficking and Function of G Protein-Coupled Receptors by Rab1 GTPase in Cardiomyocytes. In W. Balch, A. Hall, & C. Der (Eds.), Small GTPases in Disease, Part A (pp. 227-238). (Methods in Enzymology; Vol. 438). https://doi.org/10.1016/S0076-6879(07)38016-6