Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase

Thomas M. Lincoln, Xing Wu, Hassan Sellak, Nupur Dey, Chung Sik Choi

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

This basic science review examines the role of cGMP and cGMP-dependent protein kinase (PKG) in the regulation of vascular smooth muscle cell (VSMC) phenotype. The first such studies suggested a role for nitric oxide (NO) and atrial natriuretic peptides (ANP), and the downstream second messenger cGMP, in the inhibition of VSMC proliferation. Subsequently, many laboratories confirmed the anti-proliferative effects of the cGMP pathway in cultured cells and the anti-atherosclerotic effects of the pathway in in vivo animal models. Other studies suggested that the cGMP target, PKG, mediated the anti-proliferative effects of cGMP although other laboratories have not consistently observed these effects. On the other hand, PKG mediates cGMP-dependent increases in smooth muscle-specific gene expression, and in vivo studies suggest that PKG expression itself reduces vascular lesions. The mechanisms by which PKG regulates gene expression are addressed, but it still unknown how the cGMP-PKG pathway is involved in smooth muscle-specific gene expression and phenotype.

Original languageEnglish (US)
Pages (from-to)356-367
Number of pages12
JournalFrontiers in Bioscience
Volume11
Issue number1 P.1-446
DOIs
StatePublished - Feb 23 2006

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Cyclic GMP-Dependent Protein Kinases
Cyclic GMP
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
Gene expression
Phenotype
Gene Expression
Smooth Muscle
Atrial Natriuretic Factor
Second Messenger Systems
Blood Vessels
Cultured Cells
Nitric Oxide
Cell proliferation
Animal Models
Cell Proliferation
Animals

Keywords

  • Actin
  • Angiotensin receptor
  • Aorta
  • Caldesmon, calponin, and smoothelin
  • Cdk
  • Collagen
  • HMG
  • Integrin
  • Myosin
  • PKG
  • Plasminogen
  • Review
  • SM22
  • Smooth Muscle
  • TIMP
  • Vessel
  • c-myc

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase. / Lincoln, Thomas M.; Wu, Xing; Sellak, Hassan; Dey, Nupur; Choi, Chung Sik.

In: Frontiers in Bioscience, Vol. 11, No. 1 P.1-446, 23.02.2006, p. 356-367.

Research output: Contribution to journalReview article

Lincoln, Thomas M. ; Wu, Xing ; Sellak, Hassan ; Dey, Nupur ; Choi, Chung Sik. / Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase. In: Frontiers in Bioscience. 2006 ; Vol. 11, No. 1 P.1-446. pp. 356-367.
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