Régulation de la volémie au cours d'une simulation d'impesanteur de longue durée

Translated title of the contribution: Regulation of volemia during a prolonged weightlessness simulation

Marc Antoine Custaud, Eric Jacques Belin de Chantemele, Stéphane Blanc, Guillemette Gauquelin-Koch, Claude Gharib

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To study the effects of microgravity on the mechanisms involved in the regulation of body hydrous status, total body water (TBW), plasma volume (PV), and its main regulating hormones (plasma renin, aldosterone, atrial natriuretic peptide (ANP), anti-diuretic hormone (ADH)) were determined, by isotopic dilution, Dill and Costill's formula, and radioimmunologic dosages, in 9 male subjects submitted to a 90-d head-down bed rest (HDBR). ADH was determined in 24 h urinary collection as well as osmolality, sodium, and potassium. Body mass decreased (-2.8 ± 0.8 kg) as well as TBW (-7.2% ± 0.9%, i.e., -2.6 ± 0.7 kg) and PV (-4.7% ± 1.8%). Renin and aldosterone were enhanced (+109.0% ± 15.4% and +87.2% ± 38.9%, respectively). Simultaneously, we observed a decrease in ANP (-33.2% ± 20.4%). Other variables, including ADH, were not affected by HDBR. Body mass and TBW decrease (and consequently lean body mass) are associated with muscle atrophy. Renin, aldostrerone, and ANP modifications are well explained by the decrease in PV, which was not enough to induce ADH changes. It suggests that in man, the main regulatory factor for ADH secretion is osmolality, when PV is modestly and progressively decreased without arterial pressure modification, which was the case in the present protocol.

Original languageFrench
Pages (from-to)1147-1153
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Volume83
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Fingerprint

Weightlessness Simulation
Diuretics
Plasma Volume
Hormones
Body Water
Atrial Natriuretic Factor
Renin
Bed Rest
Aldosterone
Osmolar Concentration
Anethum graveolens
Head
Weightlessness
Muscular Atrophy
Potassium
Arterial Pressure
Sodium

Keywords

  • Hormone
  • Microgravity
  • Total body water
  • Volemia

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Régulation de la volémie au cours d'une simulation d'impesanteur de longue durée. / Custaud, Marc Antoine; Belin de Chantemele, Eric Jacques; Blanc, Stéphane; Gauquelin-Koch, Guillemette; Gharib, Claude.

In: Canadian Journal of Physiology and Pharmacology, Vol. 83, No. 12, 01.12.2005, p. 1147-1153.

Research output: Contribution to journalArticle

Custaud, Marc Antoine ; Belin de Chantemele, Eric Jacques ; Blanc, Stéphane ; Gauquelin-Koch, Guillemette ; Gharib, Claude. / Régulation de la volémie au cours d'une simulation d'impesanteur de longue durée. In: Canadian Journal of Physiology and Pharmacology. 2005 ; Vol. 83, No. 12. pp. 1147-1153.
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