Relation of TXA2 and PGI2 to the difference in hypoxic pulmonary vasoconstriction between different strains of rats

Yunchao Su, Jin Xian-rong

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

TXB2 and 6-keto-PGF1 α levels in arterial and venous plasma of Wistar and Hilltop rats during hypoxia were measured to investigate the roles of TXA2 and PGI2 in hypoxic pulmonary vasoconstriction (HPV) and responsiveness difference of pulmonary vessels to hypoxia between different strains of rats. The results showed that PGI2 might play an important role in maintaining the low resistance in pulmonary circulation of these two strains of rats. Increased TXA2 during hypoxia may partially mediate HPV in Wistar rats, while augmented PGI2 during hypoxia may modulate HPV in Wistar rats. This might be the important mechanism responsible for more intensive responsiveness of pulmonary vessels to hypoxia in Hilltop rats than in Wistar rats.

Original languageEnglish (US)
Pages (from-to)148-152
Number of pages5
JournalJournal of Tongji Medical University
Volume9
Issue number3
DOIs
StatePublished - Sep 1 1989
Externally publishedYes

Keywords

  • hypoxia
  • hypoxic pulmonary vasoconstriction
  • prostaglandins

ASJC Scopus subject areas

  • Management of Technology and Innovation

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