Relationship between glycosylated hemoglobin and arterial elasticity.

L. Michael Prisant, Puja Mehta, Vishal Arora, Mindy Gentry, Jennifer L Waller

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Arterial elasticity is decreased in diabetes, but it is unclear whether there is a relationship between glycosylated hemoglobin (HbA1c) and arterial elasticity. To evaluate this question, 111 subjects with diabetes mellitus had HbA1c and arterial elasticity determined in an academic outpatient setting. Three measurements of arterial elasticity indices were obtained supine using the HDI/PulseWave CR-2000 Research CardioVascular Profiling System (Hypertension Diagnostics Inc., Eagan, MN). The study population was 49% black and 51% women. Population characteristics included age, 49.2 years; duration of diabetes, 12.1 years; HbA1c, 8.9%; large artery elasticity, 11.8 mL/mm Hg x 10; and small artery elasticity, 4.7 mL/mm Hg x 100. Age correlated with diminished large artery elasticity. Women had a lower large artery elasticity than men (10.6 vs. 13.3 mL/mm Hg x 10; p = 0.0002). Decreasing small artery elasticity was associated with increasing age (p = 0.0001), HbA1c (p = 0.0184), and African-American ethnicity (p = 0.0306). Women had less small artery elasticity than men (3.8 vs. 5.8 mL/mm Hg x 100; p = 0.0001). Black diabetic patients had a reduced arterial elasticity compared with whites. Increasing HbA1c is associated with decreasing small artery elasticity, but not large artery elasticity. In diabetic patients, small artery elasticity is reduced to a greater extent in women than men and in blacks than whites.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalPreventive cardiology
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2006

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Elasticity
Glycosylated Hemoglobin A
Arteries
Population Characteristics
Cardiovascular System
African Americans
Diabetes Mellitus
Outpatients

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine

Cite this

Relationship between glycosylated hemoglobin and arterial elasticity. / Prisant, L. Michael; Mehta, Puja; Arora, Vishal; Gentry, Mindy; Waller, Jennifer L.

In: Preventive cardiology, Vol. 9, No. 3, 01.01.2006, p. 160-165.

Research output: Contribution to journalArticle

Prisant, L. Michael ; Mehta, Puja ; Arora, Vishal ; Gentry, Mindy ; Waller, Jennifer L. / Relationship between glycosylated hemoglobin and arterial elasticity. In: Preventive cardiology. 2006 ; Vol. 9, No. 3. pp. 160-165.
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