Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors.

M. Gapany, Z. P. Pavelic, S. R. Gapany, L. Pavelic, Y. G. Li, J. M. Craven, H. Jones, Paul Williams Biddinger, P. J. Stambrook, J. L. Gluckman

Research output: Contribution to journalArticle

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Abstract

This study examined the relationship between immunohistochemically detectable p53 protein and prognostic factors in squamous cell carcinoma of the head and neck (SCCHN). Twenty-seven tumor specimens were evaluated utilizing a panel of three monoclonal antibodies (MAbs) directed against different epitopes of the p53 protein (PAb 421, PAb 1801, and PAb 240). The overall incidence of p53 protein detection with a panel of MAbs was 78%, which was significantly higher than with any one of the tested antibodies. Comparison of the tumors that were negative for p53 with tumors that stained positive with one or multiple antibodies, however, revealed no statistically significant differences with respect to the stage of disease, metastatic node involvement, size of the primary tumor, or degree of tumor differentiation. The results of our study suggest that levels of p53 protein, although commonly immunohistochemically detected in head and neck tumors, do not correlate with known prognostic factors for SCCHN.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalCancer Detection and Prevention
Volume17
Issue number3
StatePublished - Jan 1 1993
Externally publishedYes

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Neck
Head
Neoplasms
Proteins
Monoclonal Antibodies
Antibodies
Epitopes
Incidence
Carcinoma, squamous cell of head and neck

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gapany, M., Pavelic, Z. P., Gapany, S. R., Pavelic, L., Li, Y. G., Craven, J. M., ... Gluckman, J. L. (1993). Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors. Cancer Detection and Prevention, 17(3), 379-386.

Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors. / Gapany, M.; Pavelic, Z. P.; Gapany, S. R.; Pavelic, L.; Li, Y. G.; Craven, J. M.; Jones, H.; Biddinger, Paul Williams; Stambrook, P. J.; Gluckman, J. L.

In: Cancer Detection and Prevention, Vol. 17, No. 3, 01.01.1993, p. 379-386.

Research output: Contribution to journalArticle

Gapany, M, Pavelic, ZP, Gapany, SR, Pavelic, L, Li, YG, Craven, JM, Jones, H, Biddinger, PW, Stambrook, PJ & Gluckman, JL 1993, 'Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors.', Cancer Detection and Prevention, vol. 17, no. 3, pp. 379-386.
Gapany M, Pavelic ZP, Gapany SR, Pavelic L, Li YG, Craven JM et al. Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors. Cancer Detection and Prevention. 1993 Jan 1;17(3):379-386.
Gapany, M. ; Pavelic, Z. P. ; Gapany, S. R. ; Pavelic, L. ; Li, Y. G. ; Craven, J. M. ; Jones, H. ; Biddinger, Paul Williams ; Stambrook, P. J. ; Gluckman, J. L. / Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors. In: Cancer Detection and Prevention. 1993 ; Vol. 17, No. 3. pp. 379-386.
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