Relationship between prenatal antibiotic use and asthma in at-risk children

Brittany Lapin, Julie Piorkowski, Dennis Randall Ownby, Sally Freels, Noel Chavez, Eva Hernandez, Cynthia Wagner-Cassanova, Darlene Pelzel, Carmen Vergara, Victoria Persky

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background Asthma prevalence has doubled in developed countries during the past 30 years. Pre- and perinatal events are essential in shaping the development of the immune system and systemic antibiotic use during this time could alter the maternal or placental microbiome, leading to an increase in the child's risk of developing asthma. Objective To determine whether prenatal antibiotic use is associated with asthma and wheezing in children at risk for asthma. Methods Using data from a randomized education intervention of families at risk for asthma from 1998 followed through 2009 in urban Chicago, asthma was defined as ever having a physician asthma diagnosis by year 3 and wheezing in the third year. Logistic regression models controlling for confounders investigated the effect of antibiotic use during pregnancy on these outcomes. Results After adjustment, prenatal antibiotic use was a risk factor for asthma (odds ratio 3.1, 95% confidence interval 1.4-6.8) but was only weakly associated with wheezing (odds ratio 1.8, 95% confidence interval 0.9-3.3). Analyses of the effects of timing of prenatal antibiotic use on asthma and wheezing showed the relation remained consistent for antibiotic use later in pregnancy, but the outcomes were not associated with antibiotic use in the first trimester. Conclusion This study suggests prenatal antibiotic use might be associated with the development of asthma in children at risk for asthma. Although the relation with prenatal antibiotics does not hold for wheezing in this study, there might be a trend that could be delineated further within a larger cohort study.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalAnnals of Allergy, Asthma and Immunology
Volume114
Issue number3
DOIs
StatePublished - Mar 1 2015

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Asthma
Anti-Bacterial Agents
Respiratory Sounds
Pregnancy Outcome
Logistic Models
Odds Ratio
Confidence Intervals
Social Adjustment
Microbiota
First Pregnancy Trimester
Developed Countries
Immune System
Cohort Studies
Mothers
Physicians
Education

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Relationship between prenatal antibiotic use and asthma in at-risk children. / Lapin, Brittany; Piorkowski, Julie; Ownby, Dennis Randall; Freels, Sally; Chavez, Noel; Hernandez, Eva; Wagner-Cassanova, Cynthia; Pelzel, Darlene; Vergara, Carmen; Persky, Victoria.

In: Annals of Allergy, Asthma and Immunology, Vol. 114, No. 3, 01.03.2015, p. 203-207.

Research output: Contribution to journalArticle

Lapin, B, Piorkowski, J, Ownby, DR, Freels, S, Chavez, N, Hernandez, E, Wagner-Cassanova, C, Pelzel, D, Vergara, C & Persky, V 2015, 'Relationship between prenatal antibiotic use and asthma in at-risk children', Annals of Allergy, Asthma and Immunology, vol. 114, no. 3, pp. 203-207. https://doi.org/10.1016/j.anai.2014.11.014
Lapin, Brittany ; Piorkowski, Julie ; Ownby, Dennis Randall ; Freels, Sally ; Chavez, Noel ; Hernandez, Eva ; Wagner-Cassanova, Cynthia ; Pelzel, Darlene ; Vergara, Carmen ; Persky, Victoria. / Relationship between prenatal antibiotic use and asthma in at-risk children. In: Annals of Allergy, Asthma and Immunology. 2015 ; Vol. 114, No. 3. pp. 203-207.
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