Relationship of body composition to stress-induced pressure natriuresis in youth

Martha E. Wilson, Gregory A. Harshfield, Luis Ortiz, Coral Hanevold, Gaston Kapuka, Lynne MacKey, Delores Gillis, Lesley Edmonds, Conner Evans

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The contribution of stress to obesity-related cardiovascular disease is uncertain. The purpose of this study was to examine the influence of body composition on stress-induced pressure natriuresis. Dual energy x-ray absorptiometry was performed in 127 African American and white youths to assess lean body mass (LBM), fat mass (FM), and total percentage of body fat (%BF). The stress protocol was comprised of a 2-h baseline period, 1-h video game competition stressor, and 2-h recovery period. Blood and urine samples were collected hourly and blood pressure (BP) was obtained at 15-min intervals. Both BP and urinary sodium excretion(U NaV) increased from baseline to stress and returned to prestress levels after stress (P =. 001 for each). The BP levels and changes were positively correlated with LBM. In contrast, levels and changes in sodium excretion U NaV were inversely correlated with FM and %BM. Multiple regression analyses that included ethnicity, sex, angiotensin II (Ang II), and measures of body composition in the models indicated the following: a) LBM was the best predictor of stress systolic BP and independently contributed with ethnicity to stress diastolic BP; b) ethnicity was the only independent predictor of the stress-related change in systolic and diastolic BP; c) LBM was the only independent predictor of the change in BP from stress to recovery for both systolic and diastolic BP; and d) total percent body fat accounted for 11.2% of the variance of stress U NaV, with Ang II contributing an additional 6.1%. Based on the results of this study, ethnicity and body composition are related to stress-induced pressure natriuresis.

Original languageEnglish (US)
Pages (from-to)1023-1028
Number of pages6
JournalAmerican journal of hypertension
Volume17
Issue number11
DOIs
StatePublished - Nov 2004

Keywords

  • Lean body mass
  • blood pressure
  • pressure natriuresis
  • race
  • stress

ASJC Scopus subject areas

  • Internal Medicine

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