Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas

J. B. Matthews, C. Scully, A. Jovanovic, I. Van der Waal, W. A. Yeudall, S. S. Prime

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29 Scopus citations


This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3% ( 4 12) of p53-positive neoplasms whereas only 7.1% ( 2 28) of p53-negative neoplasms showed an absence of these risk factors. 25% ( 3 12) of p53-positive neoplasms and 71.4% ( 20 28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalEuropean Journal of Cancer. Part B: Oral Oncology
Issue number4
Publication statusPublished - 1993
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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