Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas

J. B. Matthews, C. Scully, A. Jovanovic, I. Van der Waal, William Andrew Yeudall, S. S. Prime

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3% ( 4 12) of p53-positive neoplasms whereas only 7.1% ( 2 28) of p53-negative neoplasms showed an absence of these risk factors. 25% ( 3 12) of p53-positive neoplasms and 71.4% ( 20 28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalEuropean Journal of Cancer. Part B: Oral Oncology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Tobacco Use
Tongue
Squamous Cell Carcinoma
Alcohols
Tobacco
Neoplasms
Alcohol Drinking
Neck
Smoking
Head
Carcinoma
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas. / Matthews, J. B.; Scully, C.; Jovanovic, A.; Van der Waal, I.; Yeudall, William Andrew; Prime, S. S.

In: European Journal of Cancer. Part B: Oral Oncology, Vol. 29, No. 4, 01.01.1993, p. 285-289.

Research output: Contribution to journalArticle

Matthews, J. B. ; Scully, C. ; Jovanovic, A. ; Van der Waal, I. ; Yeudall, William Andrew ; Prime, S. S. / Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas. In: European Journal of Cancer. Part B: Oral Oncology. 1993 ; Vol. 29, No. 4. pp. 285-289.
@article{8b22e515357648c391e5dfb36992c5f4,
title = "Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas",
abstract = "This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30{\%} of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3{\%} ( 4 12) of p53-positive neoplasms whereas only 7.1{\%} ( 2 28) of p53-negative neoplasms showed an absence of these risk factors. 25{\%} ( 3 12) of p53-positive neoplasms and 71.4{\%} ( 20 28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.",
author = "Matthews, {J. B.} and C. Scully and A. Jovanovic and {Van der Waal}, I. and Yeudall, {William Andrew} and Prime, {S. S.}",
year = "1993",
month = "1",
day = "1",
doi = "10.1016/0964-1955(93)90049-K",
language = "English (US)",
volume = "29",
pages = "285--289",
journal = "European Journal of Cancer Part B: Oral Oncology",
issn = "0964-1955",
publisher = "Pergamon Press Ltd.",
number = "4",

}

TY - JOUR

T1 - Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas

AU - Matthews, J. B.

AU - Scully, C.

AU - Jovanovic, A.

AU - Van der Waal, I.

AU - Yeudall, William Andrew

AU - Prime, S. S.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3% ( 4 12) of p53-positive neoplasms whereas only 7.1% ( 2 28) of p53-negative neoplasms showed an absence of these risk factors. 25% ( 3 12) of p53-positive neoplasms and 71.4% ( 20 28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.

AB - This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3% ( 4 12) of p53-positive neoplasms whereas only 7.1% ( 2 28) of p53-negative neoplasms showed an absence of these risk factors. 25% ( 3 12) of p53-positive neoplasms and 71.4% ( 20 28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.

UR - http://www.scopus.com/inward/record.url?scp=0027425898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027425898&partnerID=8YFLogxK

U2 - 10.1016/0964-1955(93)90049-K

DO - 10.1016/0964-1955(93)90049-K

M3 - Article

VL - 29

SP - 285

EP - 289

JO - European Journal of Cancer Part B: Oral Oncology

JF - European Journal of Cancer Part B: Oral Oncology

SN - 0964-1955

IS - 4

ER -