Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

Md Nasrul Hoda, Kanchan Bhatia, Sherif S. Hafez, Maribeth H. Johnson, Shahneela Siddiqui, Adviye Ergul, Syed Kashif Zaidi, Susan C. Fagan, David C. Hess

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Remote ischemic conditioning is neuroprotective in young male rodents after experimental stroke. However, it has never been tested in females whom remain at higher risk of stroke injury after menopause. We tested remote ischemic perconditioning therapy (RIPerC) at 2 h after embolic stroke in ovariectomized (OVX) female mice with and without intravenous tissue plasminogen activator (IV-tPA) treatment. We assessed cerebral blood flow (CBF), neurobehavioral outcomes, infarction, hemorrhage, edema, and survival. RIPerC therapy with and without IV-tPA improved the CBF and neurobehavioral outcomes and reduced the infarction, hemorrhage, and edema significantly. Late IV-tPA alone at 4 h post-stroke neither improved the neurobehavior nor reduced the infarction but aggravated hemorrhage and mortality in OVX mice. RIPerC therapy prevented the increased mortality during late IV-tPA. Our study demonstrates for the first time that RIPerC therapy is effective in OVX females.

Original languageEnglish (US)
Pages (from-to)484-490
Number of pages7
JournalTranslational Stroke Research
Volume5
Issue number4
DOIs
StatePublished - Aug 1 2014

Keywords

  • Embolic stroke
  • IV-tPA thrombolysis
  • Remote ischemic conditioning
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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