Renal function in spontaneous hypertensive rats with insulin-exacerbated hypertension

Mahmood S. Mozaffari, Sanya Roysommuti, J. Michael Wyss

Research output: Contribution to journalArticle

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Abstract

This study tests the hypothesis that in spontaneously hypertensive rats (SHR), insulin decreases natriuresis and diuresis and thereby contributes importantly to the hypertensive response to exogenous insulin administration. Seven week old SHR were given daily subcutaneous injections of either insulin (mixture of 5 U/Kg regular and 10 U/Kg NPH) or vehicle (isotonic saline). Within one week of treatment, systolic arterial pressure (SAP) was significantly higher in the insulin, compared to saline, treated SHR (184.2 ± 2.5 vs. 158.3 ± 4.0 mm Hg). However, twenty-four hour sodium and fluid excretion and the natriuretic and diuretic responses to an intravenous saline load were not affected either before or after the insulin-induced exacerbation of hypertension in SHR. Insulin treatment did not affect glomerular filtration rate, effective renal blood flow, or fractional excretion of Na+ or fluid. Therefore, our data do not support a major role for sodium and fluid retention in the insulin-induced exacerbation of hypertension in SHR.

Original languageEnglish (US)
Pages (from-to)313-329
Number of pages17
JournalClinical and experimental hypertension
Volume19
Issue number3
DOIs
StatePublished - Apr 1997

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Keywords

  • blood pressure
  • glucose tolerance
  • insulin
  • natriuretic
  • renal

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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