Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension

Rana Hijazi, Jayanthi Chandar, Obioma Ikechukwu Nwobi, Samina Muneeruddin, Gastón Zilleruelo, Carolyn L. Abitbol

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Three children under the age of 3 years presented with malignant hypertension, proteinuria, and acute kidney injury. Takayasu's arteritis was diagnosed on the basis of clinical symptoms of weight loss and low grade fever in conjunction with elevated sedimentation rate and radiographic evidence of aortic and renal artery stenosis. One patient had a renal biopsy which showed arteriolar sclerosis and focal glomerulosclerosis. All three patients required multiple antihypertensive agents, ultimately including angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors. The vasculitis was treated with pulse corticosteroids followed by cyclophosphamide in one patient and mycophenolate mofetil as maintenance therapy in all. Follow-up has ranged from 2 to 8 years. Although global renal function has normalized in each patient, two have unilateral non-function of one kidney. The last patient has persistent aortic and renal artery stenosis with complex collateralization requiring ongoing medical and anticipated surgical management.

Original languageEnglish (US)
Pages (from-to)1227-1230
Number of pages4
JournalPediatric Nephrology
Volume24
Issue number6
DOIs
StatePublished - Jan 1 2009

Fingerprint

Malignant Hypertension
Takayasu Arteritis
Kidney
Renal Artery Obstruction
Arteriolosclerosis
Mycophenolic Acid
Focal Segmental Glomerulosclerosis
Angiotensin Receptor Antagonists
Vasculitis
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
Acute Kidney Injury
Cyclophosphamide
Antihypertensive Agents
Weight Loss
Adrenal Cortex Hormones
Fever
Biopsy

Keywords

  • Children
  • Renovascular hypertension
  • Vasculitis

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hijazi, R., Chandar, J., Nwobi, O. I., Muneeruddin, S., Zilleruelo, G., & Abitbol, C. L. (2009). Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension. Pediatric Nephrology, 24(6), 1227-1230. https://doi.org/10.1007/s00467-008-1088-3

Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension. / Hijazi, Rana; Chandar, Jayanthi; Nwobi, Obioma Ikechukwu; Muneeruddin, Samina; Zilleruelo, Gastón; Abitbol, Carolyn L.

In: Pediatric Nephrology, Vol. 24, No. 6, 01.01.2009, p. 1227-1230.

Research output: Contribution to journalArticle

Hijazi, R, Chandar, J, Nwobi, OI, Muneeruddin, S, Zilleruelo, G & Abitbol, CL 2009, 'Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension', Pediatric Nephrology, vol. 24, no. 6, pp. 1227-1230. https://doi.org/10.1007/s00467-008-1088-3
Hijazi R, Chandar J, Nwobi OI, Muneeruddin S, Zilleruelo G, Abitbol CL. Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension. Pediatric Nephrology. 2009 Jan 1;24(6):1227-1230. https://doi.org/10.1007/s00467-008-1088-3
Hijazi, Rana ; Chandar, Jayanthi ; Nwobi, Obioma Ikechukwu ; Muneeruddin, Samina ; Zilleruelo, Gastón ; Abitbol, Carolyn L. / Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension. In: Pediatric Nephrology. 2009 ; Vol. 24, No. 6. pp. 1227-1230.
@article{0d80b203cbe0421693787ff2a61d55c2,
title = "Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension",
abstract = "Three children under the age of 3 years presented with malignant hypertension, proteinuria, and acute kidney injury. Takayasu's arteritis was diagnosed on the basis of clinical symptoms of weight loss and low grade fever in conjunction with elevated sedimentation rate and radiographic evidence of aortic and renal artery stenosis. One patient had a renal biopsy which showed arteriolar sclerosis and focal glomerulosclerosis. All three patients required multiple antihypertensive agents, ultimately including angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors. The vasculitis was treated with pulse corticosteroids followed by cyclophosphamide in one patient and mycophenolate mofetil as maintenance therapy in all. Follow-up has ranged from 2 to 8 years. Although global renal function has normalized in each patient, two have unilateral non-function of one kidney. The last patient has persistent aortic and renal artery stenosis with complex collateralization requiring ongoing medical and anticipated surgical management.",
keywords = "Children, Renovascular hypertension, Vasculitis",
author = "Rana Hijazi and Jayanthi Chandar and Nwobi, {Obioma Ikechukwu} and Samina Muneeruddin and Gast{\'o}n Zilleruelo and Abitbol, {Carolyn L.}",
year = "2009",
month = "1",
day = "1",
doi = "10.1007/s00467-008-1088-3",
language = "English (US)",
volume = "24",
pages = "1227--1230",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Renal manifestations in toddlers with Takayasu's arteritis and malignant hypertension

AU - Hijazi, Rana

AU - Chandar, Jayanthi

AU - Nwobi, Obioma Ikechukwu

AU - Muneeruddin, Samina

AU - Zilleruelo, Gastón

AU - Abitbol, Carolyn L.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Three children under the age of 3 years presented with malignant hypertension, proteinuria, and acute kidney injury. Takayasu's arteritis was diagnosed on the basis of clinical symptoms of weight loss and low grade fever in conjunction with elevated sedimentation rate and radiographic evidence of aortic and renal artery stenosis. One patient had a renal biopsy which showed arteriolar sclerosis and focal glomerulosclerosis. All three patients required multiple antihypertensive agents, ultimately including angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors. The vasculitis was treated with pulse corticosteroids followed by cyclophosphamide in one patient and mycophenolate mofetil as maintenance therapy in all. Follow-up has ranged from 2 to 8 years. Although global renal function has normalized in each patient, two have unilateral non-function of one kidney. The last patient has persistent aortic and renal artery stenosis with complex collateralization requiring ongoing medical and anticipated surgical management.

AB - Three children under the age of 3 years presented with malignant hypertension, proteinuria, and acute kidney injury. Takayasu's arteritis was diagnosed on the basis of clinical symptoms of weight loss and low grade fever in conjunction with elevated sedimentation rate and radiographic evidence of aortic and renal artery stenosis. One patient had a renal biopsy which showed arteriolar sclerosis and focal glomerulosclerosis. All three patients required multiple antihypertensive agents, ultimately including angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors. The vasculitis was treated with pulse corticosteroids followed by cyclophosphamide in one patient and mycophenolate mofetil as maintenance therapy in all. Follow-up has ranged from 2 to 8 years. Although global renal function has normalized in each patient, two have unilateral non-function of one kidney. The last patient has persistent aortic and renal artery stenosis with complex collateralization requiring ongoing medical and anticipated surgical management.

KW - Children

KW - Renovascular hypertension

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=67650320910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650320910&partnerID=8YFLogxK

U2 - 10.1007/s00467-008-1088-3

DO - 10.1007/s00467-008-1088-3

M3 - Article

VL - 24

SP - 1227

EP - 1230

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 6

ER -