TY - JOUR
T1 - Renin-angiotensin-aldosterone system in healthy subjects aged ten to eighteen years
AU - Harshfield, Gregory A.
AU - Alpert, Bruce S.
AU - Pulliam, Derrick A.
N1 - Funding Information:
The renin-angiotensin-aldosterone system plays a critical role in the regulation of electrolyte balance and blood pressure. Research on the functioning of the RAAS in adults has established normative data for both plasma renin activity and plasma aldosterone concentration. 1'2 In addition, research on normotensive and hypertensive adults has shown that age, 3"5 race, 5,6 gender,7 family history of hypertension, s and sodium intake 9,1~ all influence PRA. Factors shown to influence plasma aldosterone concentration include PRA, s, II family history of hypertension, 8' 12 potassium intake, 12 plasma corticotropin and serum cortisol levels, 13 and sodium intake. 9 The study of the RAAS, particularly aldosterone, in children and adolescents has received Supported by National Institutes of Health grants HL-35788, HL-42645, and GCRC M01-RR0021. Submitted for publication April 15, 1992; accepted Oct. 30, 1992. Reprint requests: Gregory A. Harshfield, PhD, University of Tennessee, Memphis, 777 Washington Ave., Suite 215, Memphis, TN 38105. Copyright 9 1993 by Mosby-Year Book, Inc. 0022-3476/93/$I.00 + .I0 9/20/43886 considerably less attention. Furthermore, the results of these studies have been inconsistent, t4"21 Therefore the purpose of our investigation was to provide additional normative data for PRA and plasma aldosterone concentration, and to examine determinants of PRA and plasma aldosterone concentration in a large biracial sample of healthy, normotensive children and adolescents. The factors that we studied included age, race, gender, family history of hypertension, and electrolyte intake (as reflected by excretion).
PY - 1993/4
Y1 - 1993/4
N2 - We abtained normative data for plasma renin activity (PRA) and plasma aldosterone concentration from a biracial sample of 195 healthy, normotensive children and adolescents aged 10 to 18 years. The sample Included 119 boys and 76 girls, of whom 103 were black and 92 were white. The mean PRA value (±SD) was 2.52±1.95ng/ml per hour, with minimal and maximal values of 0.1 and 13.50 ng/ml per hour. The mean plasma aldosterone concentration was 12.56±8.59 ng/ml, with minimal and maximal values of 1.6 and 50.1 ng/ml. We also examined the effects of subject characteristics and electrolyte intake. The slope relating sodium excretion to PRA was negative and highly significant (slope=-0.01; p<0.003). The slope relating PRA to plasma aldosterone concentration was positive and highly significant (slope=1.59; p<0.0001). We did not observe differences in either variable as a function of age, sex, race, or family history of hypertension. These results suggest that differences based on race and family history of hypertension observed in adults are not present in youth.
AB - We abtained normative data for plasma renin activity (PRA) and plasma aldosterone concentration from a biracial sample of 195 healthy, normotensive children and adolescents aged 10 to 18 years. The sample Included 119 boys and 76 girls, of whom 103 were black and 92 were white. The mean PRA value (±SD) was 2.52±1.95ng/ml per hour, with minimal and maximal values of 0.1 and 13.50 ng/ml per hour. The mean plasma aldosterone concentration was 12.56±8.59 ng/ml, with minimal and maximal values of 1.6 and 50.1 ng/ml. We also examined the effects of subject characteristics and electrolyte intake. The slope relating sodium excretion to PRA was negative and highly significant (slope=-0.01; p<0.003). The slope relating PRA to plasma aldosterone concentration was positive and highly significant (slope=1.59; p<0.0001). We did not observe differences in either variable as a function of age, sex, race, or family history of hypertension. These results suggest that differences based on race and family history of hypertension observed in adults are not present in youth.
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U2 - 10.1016/S0022-3476(05)83536-X
DO - 10.1016/S0022-3476(05)83536-X
M3 - Article
C2 - 8463901
AN - SCOPUS:0027405645
SN - 0022-3476
VL - 122
SP - 563
EP - 567
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 4
ER -