Renin production after experimental extracorporeal shock wave lithotripsy: a primate model.

Durwood Earnest Neal, M. B. Kaack, E. P. Harmon, F. Puyau, A. Morvant, E. Richardson, R. Thomas

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Since the advent of extracorporeal shock wave lithotripsy (ESWL) concern has surfaced as to the long-term risk of the development of hypertension, as well as risk to the developing kidney. To study this concern 8 infant and 3 adult rhesus monkeys (Macaca mulatta) underwent treatment with the XL1 experimental lithotriptor to 1 kidney varying the amount of voltage and shocks. Followup consisted of measurement of renin levels and quantitative renal scans, using 131iodine hippurate to calculate effective renal plasma flow. In the infants a slight change was noted in the absolute effective renal plasma flow of the treated kidney versus the untreated side but it was not statistically different. When indexed to body surface area in the growing animal, there was a statistically significant decrease in renal function. However, peripheral renin levels were markedly elevated in the infants at 3 weeks, and they gradually declined during the 6-month period, although levels remained elevated over baseline. The adults also had central renin levels drawn from the renal vein on the treated side, and there was a close correlation with the peripheral levels, which peaked at 3 weeks and returned to normal. Thus, it seems that at least in the short term renin production is increased in infants more than adults. This finding may be an indicator as to renal damage and is a possible explanation for hypertension occurring after ESWL.

Original languageEnglish (US)
Pages (from-to)548-550
Number of pages3
JournalThe Journal of urology
Volume146
Issue number2 ( Pt 2)
StatePublished - Jan 1 1991
Externally publishedYes

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Lithotripsy
Renin
Primates
Kidney
Effective Renal Plasma Flow
Macaca mulatta
Hypertension
Renal Veins
Body Surface Area
Shock

ASJC Scopus subject areas

  • Urology

Cite this

Neal, D. E., Kaack, M. B., Harmon, E. P., Puyau, F., Morvant, A., Richardson, E., & Thomas, R. (1991). Renin production after experimental extracorporeal shock wave lithotripsy: a primate model. The Journal of urology, 146(2 ( Pt 2)), 548-550.

Renin production after experimental extracorporeal shock wave lithotripsy : a primate model. / Neal, Durwood Earnest; Kaack, M. B.; Harmon, E. P.; Puyau, F.; Morvant, A.; Richardson, E.; Thomas, R.

In: The Journal of urology, Vol. 146, No. 2 ( Pt 2), 01.01.1991, p. 548-550.

Research output: Contribution to journalArticle

Neal, DE, Kaack, MB, Harmon, EP, Puyau, F, Morvant, A, Richardson, E & Thomas, R 1991, 'Renin production after experimental extracorporeal shock wave lithotripsy: a primate model.', The Journal of urology, vol. 146, no. 2 ( Pt 2), pp. 548-550.
Neal DE, Kaack MB, Harmon EP, Puyau F, Morvant A, Richardson E et al. Renin production after experimental extracorporeal shock wave lithotripsy: a primate model. The Journal of urology. 1991 Jan 1;146(2 ( Pt 2)):548-550.
Neal, Durwood Earnest ; Kaack, M. B. ; Harmon, E. P. ; Puyau, F. ; Morvant, A. ; Richardson, E. ; Thomas, R. / Renin production after experimental extracorporeal shock wave lithotripsy : a primate model. In: The Journal of urology. 1991 ; Vol. 146, No. 2 ( Pt 2). pp. 548-550.
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