Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application

U. M. Wikesjö, N. Claffey, L. A. Christersson, L. C. Franzetti, R. J. Genco, V. P. Terranova, J. Egelberg

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Abstract This study examines the effects of root surface demineralization and topical fibronectin as adjuncts to reconstructive periodontal surgery. In 14 beagle dogs, horizontal periodontal defects were surgically induced around the mandibular premolars followed by a 6‐week period without plaque control. Reconstructive surgery of the defects was subsequently carried out. The root surfaces were debrided and superficially demineralized with citric acid or tetracycline hydrochloride, with or without subsequent application of fibronectin, Muco‐periosteal flaps were raised to cover most of the crowns and sutured. The animals were sacrificed 12 weeks after surgery and block sections of the teeth and surrounding tissues were processed for histology. Analysis included incidence of furcation defects presenting with an epithelial lining, quantification of connective tissue repair relative to the furcation circumference, and regeneration of alveolar bone relative to the furcation defect height. The incidence of root resorption and ankylosis was also analyzed. Within the limitations of this study it was concluded that: (1) citric acid conditioning of the root surface frequently resulted in complete connective tissue repair of the furcation defect; (2) root resorption and ankylosis were prevalent features of the healing response: (3) citric acid and tetracycline treatment had similar potential to induce connective tissue repair and resulted in corresponding incidences of root resorption and ankylosis: (4) application of fibronectin to demineralized root surfaces did not enhance the amount of connective tissue repair and did not alter the pattern of root resorption and ankylosis.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalJournal of Clinical Periodontology
Volume15
Issue number1
DOIs
StatePublished - Jan 1988

Fingerprint

Reconstructive Surgical Procedures
Furcation Defects
Root Resorption
Ankylosis
Tetracycline
Fibronectins
Connective Tissue
Citric Acid
Dogs
Incidence
Bone Regeneration
Bicuspid
Crowns
Histology
Tooth

Keywords

  • Periodontium
  • citric acid
  • fibronectin
  • tetracycline
  • wound healing

ASJC Scopus subject areas

  • Periodontics

Cite this

Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application. / Wikesjö, U. M.; Claffey, N.; Christersson, L. A.; Franzetti, L. C.; Genco, R. J.; Terranova, V. P.; Egelberg, J.

In: Journal of Clinical Periodontology, Vol. 15, No. 1, 01.1988, p. 73-80.

Research output: Contribution to journalArticle

Wikesjö, U. M. ; Claffey, N. ; Christersson, L. A. ; Franzetti, L. C. ; Genco, R. J. ; Terranova, V. P. ; Egelberg, J. / Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application. In: Journal of Clinical Periodontology. 1988 ; Vol. 15, No. 1. pp. 73-80.
@article{5dae0dbdcb114be88c8eaee44546caa4,
title = "Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application",
abstract = "Abstract This study examines the effects of root surface demineralization and topical fibronectin as adjuncts to reconstructive periodontal surgery. In 14 beagle dogs, horizontal periodontal defects were surgically induced around the mandibular premolars followed by a 6‐week period without plaque control. Reconstructive surgery of the defects was subsequently carried out. The root surfaces were debrided and superficially demineralized with citric acid or tetracycline hydrochloride, with or without subsequent application of fibronectin, Muco‐periosteal flaps were raised to cover most of the crowns and sutured. The animals were sacrificed 12 weeks after surgery and block sections of the teeth and surrounding tissues were processed for histology. Analysis included incidence of furcation defects presenting with an epithelial lining, quantification of connective tissue repair relative to the furcation circumference, and regeneration of alveolar bone relative to the furcation defect height. The incidence of root resorption and ankylosis was also analyzed. Within the limitations of this study it was concluded that: (1) citric acid conditioning of the root surface frequently resulted in complete connective tissue repair of the furcation defect; (2) root resorption and ankylosis were prevalent features of the healing response: (3) citric acid and tetracycline treatment had similar potential to induce connective tissue repair and resulted in corresponding incidences of root resorption and ankylosis: (4) application of fibronectin to demineralized root surfaces did not enhance the amount of connective tissue repair and did not alter the pattern of root resorption and ankylosis.",
keywords = "Periodontium, citric acid, fibronectin, tetracycline, wound healing",
author = "Wikesj{\"o}, {U. M.} and N. Claffey and Christersson, {L. A.} and Franzetti, {L. C.} and Genco, {R. J.} and Terranova, {V. P.} and J. Egelberg",
year = "1988",
month = "1",
doi = "10.1111/j.1600-051X.1988.tb01558.x",
language = "English (US)",
volume = "15",
pages = "73--80",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Blackwell Munksgaard",
number = "1",

}

TY - JOUR

T1 - Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application

AU - Wikesjö, U. M.

AU - Claffey, N.

AU - Christersson, L. A.

AU - Franzetti, L. C.

AU - Genco, R. J.

AU - Terranova, V. P.

AU - Egelberg, J.

PY - 1988/1

Y1 - 1988/1

N2 - Abstract This study examines the effects of root surface demineralization and topical fibronectin as adjuncts to reconstructive periodontal surgery. In 14 beagle dogs, horizontal periodontal defects were surgically induced around the mandibular premolars followed by a 6‐week period without plaque control. Reconstructive surgery of the defects was subsequently carried out. The root surfaces were debrided and superficially demineralized with citric acid or tetracycline hydrochloride, with or without subsequent application of fibronectin, Muco‐periosteal flaps were raised to cover most of the crowns and sutured. The animals were sacrificed 12 weeks after surgery and block sections of the teeth and surrounding tissues were processed for histology. Analysis included incidence of furcation defects presenting with an epithelial lining, quantification of connective tissue repair relative to the furcation circumference, and regeneration of alveolar bone relative to the furcation defect height. The incidence of root resorption and ankylosis was also analyzed. Within the limitations of this study it was concluded that: (1) citric acid conditioning of the root surface frequently resulted in complete connective tissue repair of the furcation defect; (2) root resorption and ankylosis were prevalent features of the healing response: (3) citric acid and tetracycline treatment had similar potential to induce connective tissue repair and resulted in corresponding incidences of root resorption and ankylosis: (4) application of fibronectin to demineralized root surfaces did not enhance the amount of connective tissue repair and did not alter the pattern of root resorption and ankylosis.

AB - Abstract This study examines the effects of root surface demineralization and topical fibronectin as adjuncts to reconstructive periodontal surgery. In 14 beagle dogs, horizontal periodontal defects were surgically induced around the mandibular premolars followed by a 6‐week period without plaque control. Reconstructive surgery of the defects was subsequently carried out. The root surfaces were debrided and superficially demineralized with citric acid or tetracycline hydrochloride, with or without subsequent application of fibronectin, Muco‐periosteal flaps were raised to cover most of the crowns and sutured. The animals were sacrificed 12 weeks after surgery and block sections of the teeth and surrounding tissues were processed for histology. Analysis included incidence of furcation defects presenting with an epithelial lining, quantification of connective tissue repair relative to the furcation circumference, and regeneration of alveolar bone relative to the furcation defect height. The incidence of root resorption and ankylosis was also analyzed. Within the limitations of this study it was concluded that: (1) citric acid conditioning of the root surface frequently resulted in complete connective tissue repair of the furcation defect; (2) root resorption and ankylosis were prevalent features of the healing response: (3) citric acid and tetracycline treatment had similar potential to induce connective tissue repair and resulted in corresponding incidences of root resorption and ankylosis: (4) application of fibronectin to demineralized root surfaces did not enhance the amount of connective tissue repair and did not alter the pattern of root resorption and ankylosis.

KW - Periodontium

KW - citric acid

KW - fibronectin

KW - tetracycline

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=0023779070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023779070&partnerID=8YFLogxK

U2 - 10.1111/j.1600-051X.1988.tb01558.x

DO - 10.1111/j.1600-051X.1988.tb01558.x

M3 - Article

C2 - 3422248

AN - SCOPUS:0023779070

VL - 15

SP - 73

EP - 80

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 1

ER -