repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system

Wen Cheng Xiong, Hideyuki Okano, Nipam H. Patel, Julie A. Blendy, Craig Montell

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles were viable but affected glia in the optic lobe, resulting in a reversal in polarity of the electrophysiological response to light in the adult. Strong repo alleles caused defects in embryonic glia and resulted in embryonic lethality. Expression of repo appeared to be specific to glia throughout development. In the adult visual system, repo was expressed in laminal glia, medullar glia, and subretinal cells; in the embryo, repo was expressed in nearly all of the identified glia in the central and peripheral nervous systems except midline glia. The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development.

Original languageEnglish (US)
Pages (from-to)981-994
Number of pages14
JournalGenes and Development
Volume8
Issue number8
DOIs
StatePublished - Apr 15 1994

Fingerprint

Homeodomain Proteins
Neuroglia
Nervous System
Drosophila
Alleles
Peripheral Nervous System
Regulator Genes
Embryonic Structures
Central Nervous System
Light

Keywords

  • development
  • Drosophila
  • glia
  • homeo domain
  • neurogenesis
  • vision

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system. / Xiong, Wen Cheng; Okano, Hideyuki; Patel, Nipam H.; Blendy, Julie A.; Montell, Craig.

In: Genes and Development, Vol. 8, No. 8, 15.04.1994, p. 981-994.

Research output: Contribution to journalArticle

Xiong, Wen Cheng ; Okano, Hideyuki ; Patel, Nipam H. ; Blendy, Julie A. ; Montell, Craig. / repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system. In: Genes and Development. 1994 ; Vol. 8, No. 8. pp. 981-994.
@article{014b65f74e634d41a65074cb8b946b3e,
title = "repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system",
abstract = "We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles were viable but affected glia in the optic lobe, resulting in a reversal in polarity of the electrophysiological response to light in the adult. Strong repo alleles caused defects in embryonic glia and resulted in embryonic lethality. Expression of repo appeared to be specific to glia throughout development. In the adult visual system, repo was expressed in laminal glia, medullar glia, and subretinal cells; in the embryo, repo was expressed in nearly all of the identified glia in the central and peripheral nervous systems except midline glia. The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development.",
keywords = "development, Drosophila, glia, homeo domain, neurogenesis, vision",
author = "Xiong, {Wen Cheng} and Hideyuki Okano and Patel, {Nipam H.} and Blendy, {Julie A.} and Craig Montell",
year = "1994",
month = "4",
day = "15",
doi = "10.1101/gad.8.8.981",
language = "English (US)",
volume = "8",
pages = "981--994",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "8",

}

TY - JOUR

T1 - repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system

AU - Xiong, Wen Cheng

AU - Okano, Hideyuki

AU - Patel, Nipam H.

AU - Blendy, Julie A.

AU - Montell, Craig

PY - 1994/4/15

Y1 - 1994/4/15

N2 - We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles were viable but affected glia in the optic lobe, resulting in a reversal in polarity of the electrophysiological response to light in the adult. Strong repo alleles caused defects in embryonic glia and resulted in embryonic lethality. Expression of repo appeared to be specific to glia throughout development. In the adult visual system, repo was expressed in laminal glia, medullar glia, and subretinal cells; in the embryo, repo was expressed in nearly all of the identified glia in the central and peripheral nervous systems except midline glia. The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development.

AB - We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles were viable but affected glia in the optic lobe, resulting in a reversal in polarity of the electrophysiological response to light in the adult. Strong repo alleles caused defects in embryonic glia and resulted in embryonic lethality. Expression of repo appeared to be specific to glia throughout development. In the adult visual system, repo was expressed in laminal glia, medullar glia, and subretinal cells; in the embryo, repo was expressed in nearly all of the identified glia in the central and peripheral nervous systems except midline glia. The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development.

KW - development

KW - Drosophila

KW - glia

KW - homeo domain

KW - neurogenesis

KW - vision

UR - http://www.scopus.com/inward/record.url?scp=0028281992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028281992&partnerID=8YFLogxK

U2 - 10.1101/gad.8.8.981

DO - 10.1101/gad.8.8.981

M3 - Article

C2 - 7926782

AN - SCOPUS:0028281992

VL - 8

SP - 981

EP - 994

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 8

ER -