TY - JOUR
T1 - Report From the International Atomic Energy Agency (IAEA) Consultants' Meeting on Elective Nodal Irradiation in Lung Cancer
T2 - Non-Small-Cell Lung Cancer (NSCLC)
AU - Belderbos, José S.A.
AU - Kepka, Lucyna
AU - (Spring) Kong, Feng Ming
AU - Martel, Mary K.
AU - Videtic, Gregory M.M.
AU - Jeremic, Branislav
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Lymphatic spread is an important pathway of progression in non-small-cell lung cancer (NSCLC), along with local spread and distant metastasis. The probability of lymph node (LN) involvement is dependent on the site of the primary tumor, stage, and histology. Elective nodal irradiation (ENI) is the irradiation of clinical and radiological uninvolved LN to account for microscopic tumor invasion in these LNs because we have not been able to determine the extent of LN spread accurately. The clinical value of ENI is uncertain. The impact of ENI is dependent on many (staging-, treatment-, and patient-related) factors. The purpose of this report is to analyze the current status of ENI and to provide comprehensive in-depth analysis and guidance on how to generally approach this issue in NSCLC.
AB - Lymphatic spread is an important pathway of progression in non-small-cell lung cancer (NSCLC), along with local spread and distant metastasis. The probability of lymph node (LN) involvement is dependent on the site of the primary tumor, stage, and histology. Elective nodal irradiation (ENI) is the irradiation of clinical and radiological uninvolved LN to account for microscopic tumor invasion in these LNs because we have not been able to determine the extent of LN spread accurately. The clinical value of ENI is uncertain. The impact of ENI is dependent on many (staging-, treatment-, and patient-related) factors. The purpose of this report is to analyze the current status of ENI and to provide comprehensive in-depth analysis and guidance on how to generally approach this issue in NSCLC.
KW - Elective nodal irradiation
KW - Involved-field irradiation
KW - Isolated nodal failure
KW - Non-small-cell lung cancer
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U2 - 10.1016/j.ijrobp.2008.04.081
DO - 10.1016/j.ijrobp.2008.04.081
M3 - Article
C2 - 18793952
AN - SCOPUS:51449108879
SN - 0360-3016
VL - 72
SP - 335
EP - 342
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 2
ER -