Abstract
Purpose: To investigate methods of reporting and analyzing statistical uncertainties in doses to targets and normal tissues in Monte Carlo (MC)-based treatment planning. Methods and Materials: Methods for quantifying statistical uncertainties in dose, such as uncertainty specification to specific dose points, or to volume-based regions, were analyzed in MC-based treatment planning for 5 lung cancer patients. The effect of statistical uncertainties on target and normal tissue dose indices was evaluated. The concept of uncertainty volume histograms for targets and organs at risk was examined, along with its utility, in conjunction with dose volume histograms, in assessing the acceptability of the statistical precision in dose distributions. The uncertainty evaluation tools were extended to four-dimensional planning for application on multiple instances of the patient geometry. All calculations were performed using the Dose Planning Method MC code. Results: For targets, generalized equivalent uniform doses and mean target doses converged at 150 million simulated histories, corresponding to relative uncertainties of less than 2% in the mean target doses. For the normal lung tissue (a volume-effect organ), mean lung dose and normal tissue complication probability converged at 150 million histories despite the large range in the relative organ uncertainty volume histograms. For "serial" normal tissues such as the spinal cord, large fluctuations exist in point dose relative uncertainties. Conclusions: The tools presented here provide useful means for evaluating statistical precision in MC-based dose distributions. Tradeoffs between uncertainties in doses to targets, volume-effect organs, and "serial" normal tissues must be considered carefully in determining acceptable levels of statistical precision in MC-computed dose distributions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1249-1259 |
| Number of pages | 11 |
| Journal | International Journal of Radiation Oncology Biology Physics |
| Volume | 65 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 15 2006 |
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Keywords
- Dose distributions
- Lung cancer
- Monte Carlo-based treatment planning
- Statistical uncertainties
- Uncertainty volume histograms
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
Reporting and analyzing statistical uncertainties in Monte Carlo-based treatment planning. / Chetty, Indrin J.; Rosu, Mihaela; Kessler, Marc L.; Fraass, Benedick A.; Ten Haken, Randall K.; Kong, Feng Ming (Spring); McShan, Daniel L.
In: International Journal of Radiation Oncology Biology Physics, Vol. 65, No. 4, 15.07.2006, p. 1249-1259.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reporting and analyzing statistical uncertainties in Monte Carlo-based treatment planning
AU - Chetty, Indrin J.
AU - Rosu, Mihaela
AU - Kessler, Marc L.
AU - Fraass, Benedick A.
AU - Ten Haken, Randall K.
AU - Kong, Feng Ming (Spring)
AU - McShan, Daniel L.
PY - 2006/7/15
Y1 - 2006/7/15
N2 - Purpose: To investigate methods of reporting and analyzing statistical uncertainties in doses to targets and normal tissues in Monte Carlo (MC)-based treatment planning. Methods and Materials: Methods for quantifying statistical uncertainties in dose, such as uncertainty specification to specific dose points, or to volume-based regions, were analyzed in MC-based treatment planning for 5 lung cancer patients. The effect of statistical uncertainties on target and normal tissue dose indices was evaluated. The concept of uncertainty volume histograms for targets and organs at risk was examined, along with its utility, in conjunction with dose volume histograms, in assessing the acceptability of the statistical precision in dose distributions. The uncertainty evaluation tools were extended to four-dimensional planning for application on multiple instances of the patient geometry. All calculations were performed using the Dose Planning Method MC code. Results: For targets, generalized equivalent uniform doses and mean target doses converged at 150 million simulated histories, corresponding to relative uncertainties of less than 2% in the mean target doses. For the normal lung tissue (a volume-effect organ), mean lung dose and normal tissue complication probability converged at 150 million histories despite the large range in the relative organ uncertainty volume histograms. For "serial" normal tissues such as the spinal cord, large fluctuations exist in point dose relative uncertainties. Conclusions: The tools presented here provide useful means for evaluating statistical precision in MC-based dose distributions. Tradeoffs between uncertainties in doses to targets, volume-effect organs, and "serial" normal tissues must be considered carefully in determining acceptable levels of statistical precision in MC-computed dose distributions.
AB - Purpose: To investigate methods of reporting and analyzing statistical uncertainties in doses to targets and normal tissues in Monte Carlo (MC)-based treatment planning. Methods and Materials: Methods for quantifying statistical uncertainties in dose, such as uncertainty specification to specific dose points, or to volume-based regions, were analyzed in MC-based treatment planning for 5 lung cancer patients. The effect of statistical uncertainties on target and normal tissue dose indices was evaluated. The concept of uncertainty volume histograms for targets and organs at risk was examined, along with its utility, in conjunction with dose volume histograms, in assessing the acceptability of the statistical precision in dose distributions. The uncertainty evaluation tools were extended to four-dimensional planning for application on multiple instances of the patient geometry. All calculations were performed using the Dose Planning Method MC code. Results: For targets, generalized equivalent uniform doses and mean target doses converged at 150 million simulated histories, corresponding to relative uncertainties of less than 2% in the mean target doses. For the normal lung tissue (a volume-effect organ), mean lung dose and normal tissue complication probability converged at 150 million histories despite the large range in the relative organ uncertainty volume histograms. For "serial" normal tissues such as the spinal cord, large fluctuations exist in point dose relative uncertainties. Conclusions: The tools presented here provide useful means for evaluating statistical precision in MC-based dose distributions. Tradeoffs between uncertainties in doses to targets, volume-effect organs, and "serial" normal tissues must be considered carefully in determining acceptable levels of statistical precision in MC-computed dose distributions.
KW - Dose distributions
KW - Lung cancer
KW - Monte Carlo-based treatment planning
KW - Statistical uncertainties
KW - Uncertainty volume histograms
UR - http://www.scopus.com/inward/record.url?scp=33745184007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745184007&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2006.03.039
DO - 10.1016/j.ijrobp.2006.03.039
M3 - Article
C2 - 16798417
AN - SCOPUS:33745184007
VL - 65
SP - 1249
EP - 1259
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 4
ER -