Requirement for math5 in the development of retinal ganglion cells

Steven W. Wang, Byong Su Kim, Kan Ding, Huan Wang, Dantong Sun, Randy L. Johnson, William H. Klein, Lin Gan

Research output: Contribution to journalArticle

Abstract

math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalGenes and Development
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Retinal Ganglion Cells
Essential Genes
Cell Differentiation
Amacrine Cells
Drosophila

Keywords

  • bHLH
  • brn-3b
  • math5
  • POU-domain
  • Retinal development

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Wang, S. W., Kim, B. S., Ding, K., Wang, H., Sun, D., Johnson, R. L., ... Gan, L. (2001). Requirement for math5 in the development of retinal ganglion cells. Genes and Development, 15(1), 24-29. https://doi.org/10.1101/gad.855301

Requirement for math5 in the development of retinal ganglion cells. / Wang, Steven W.; Kim, Byong Su; Ding, Kan; Wang, Huan; Sun, Dantong; Johnson, Randy L.; Klein, William H.; Gan, Lin.

In: Genes and Development, Vol. 15, No. 1, 01.01.2001, p. 24-29.

Research output: Contribution to journalArticle

Wang, SW, Kim, BS, Ding, K, Wang, H, Sun, D, Johnson, RL, Klein, WH & Gan, L 2001, 'Requirement for math5 in the development of retinal ganglion cells', Genes and Development, vol. 15, no. 1, pp. 24-29. https://doi.org/10.1101/gad.855301
Wang SW, Kim BS, Ding K, Wang H, Sun D, Johnson RL et al. Requirement for math5 in the development of retinal ganglion cells. Genes and Development. 2001 Jan 1;15(1):24-29. https://doi.org/10.1101/gad.855301
Wang, Steven W. ; Kim, Byong Su ; Ding, Kan ; Wang, Huan ; Sun, Dantong ; Johnson, Randy L. ; Klein, William H. ; Gan, Lin. / Requirement for math5 in the development of retinal ganglion cells. In: Genes and Development. 2001 ; Vol. 15, No. 1. pp. 24-29.
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