Requirement for math5 in the development of retinal ganglion cells

Steven W. Wang; Byong Su Kim; Kan Ding; Huan Wang; Dantong Sun; Randy L. Johnson; William H. Klein; Lin Gan

doi:10.1101/gad.855301

Requirement for math5 in the development of retinal ganglion cells

Steven W. Wang, Byong Su Kim, Kan Ding, Huan Wang, Dantong Sun, Randy L. Johnson, William H. Klein, Lin Gan

Research output: Contribution to journal › Article › peer-review

404 Scopus citations

Abstract

math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.

Original language	English (US)
Pages (from-to)	24-29
Number of pages	6
Journal	Genes and Development
Volume	15
Issue number	1
DOIs	https://doi.org/10.1101/gad.855301
State	Published - Jan 1 2001
Externally published	Yes

Keywords

POU-domain
Retinal development
bHLH
brn-3b
math5

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.855301

Cite this

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abstract = "math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.",

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AU - Wang, Steven W.

AU - Kim, Byong Su

AU - Ding, Kan

AU - Wang, Huan

AU - Sun, Dantong

AU - Johnson, Randy L.

AU - Klein, William H.

AU - Gan, Lin

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Requirement for math5 in the development of retinal ganglion cells

Abstract

Keywords

ASJC Scopus subject areas

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