Requirement for math5 in the development of retinal ganglion cells

Steven W. Wang, Byong Su Kim, Kan Ding, Huan Wang, Dantong Sun, Randy L. Johnson, William H. Klein, Lin Gan

Research output: Contribution to journalArticle

367 Scopus citations

Abstract

math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalGenes and Development
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • POU-domain
  • Retinal development
  • bHLH
  • brn-3b
  • math5

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Fingerprint Dive into the research topics of 'Requirement for math5 in the development of retinal ganglion cells'. Together they form a unique fingerprint.

  • Cite this

    Wang, S. W., Kim, B. S., Ding, K., Wang, H., Sun, D., Johnson, R. L., Klein, W. H., & Gan, L. (2001). Requirement for math5 in the development of retinal ganglion cells. Genes and Development, 15(1), 24-29. https://doi.org/10.1101/gad.855301