Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout

Zhenzhong Cui, Kathryn A. Lindl, Bing Mei, Shuqing Zhang, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We employed an inducible, reversible and region-specific gene knockout technique to investigate the requirements for cortical NMDA receptors (NMDAR) during the various stages (acquisition, consolidation and storage, and retrieval) of nondeclarative, hippocampal-independent memory in mice using a conditioned taste aversion memory paradigm. Here we show that temporary knockout of the cortical NMDAR during either the learning or postlearning consolidation stage, but not during the retrieval stage, causes severe performance deficits in the 1-month taste memory retention tests. More importantly, we found that the consolidation and storage of the long-term nondeclarative taste memories requires cortical NMDAR reactivation. Thus, the dynamic engagement of the NMDAR during the postlearning stage leads us to postulate that NMDAR reactivation-mediated synaptic re-entry reinforcement is crucial for overcoming the destabilizing effects intrinsic to synaptic protein turnover and for achieving consolidation and storage of nondeclarative memories in the brain.

Original languageEnglish (US)
Pages (from-to)755-763
Number of pages9
JournalEuropean Journal of Neuroscience
Volume22
Issue number3
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

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N-Methyl-D-Aspartate Receptors
Gene Knockout Techniques
Learning
Brain
Proteins

Keywords

  • Conditioned taste aversion
  • Long-term memory
  • SRR
  • Synaptic re-entry reinforcement

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout. / Cui, Zhenzhong; Lindl, Kathryn A.; Mei, Bing; Zhang, Shuqing; Tsien, Joseph Zhuo.

In: European Journal of Neuroscience, Vol. 22, No. 3, 01.08.2005, p. 755-763.

Research output: Contribution to journalArticle

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AU - Mei, Bing

AU - Zhang, Shuqing

AU - Tsien, Joseph Zhuo

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