Research progress of phosphodiesterases and phosphodiesterase inhibitors

Chang Liang Chen, Shuang Huang

Research output: Contribution to journalReview article

Abstract

Intracellular levels of ubiquitous transduction signal cyclic adenosine 3′, 5′-monophosphate (cAMP) and cyclic guanosine 3′, 5′-monophosphate (cGMP) are partly determined by the hydrolysis by phosphodiesterases (PDEs). So far, the superfamily of PDE is composed of at least 11 isoforms and each family is characterized with unique cellular distribution, expression, regulation mode and inhibitor sensitivity, and PDEs are considered to be involved in a variety of pathological processes, such as inflammation, asthma, depression, and erectile dysfunction, etc. Currently, these characteristics draw PDEs more and more attention as great targets for drugs. In this review, the basic biochemical properties, cellular regulation, expression pattern, physiological functions and inhibitors of different PDE isoforms will be briefly discussed.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalChinese Pharmacological Bulletin
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2014

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Keywords

  • PDE
  • PDE inhibitors
  • PDE4
  • PDE5
  • cAMP
  • cGMP

ASJC Scopus subject areas

  • Pharmacology

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