Research progress of phosphodiesterases and phosphodiesterase inhibitors

Chang Liang Chen, Shuang Huang

Research output: Contribution to journalReview article

Abstract

Intracellular levels of ubiquitous transduction signal cyclic adenosine 3′, 5′-monophosphate (cAMP) and cyclic guanosine 3′, 5′-monophosphate (cGMP) are partly determined by the hydrolysis by phosphodiesterases (PDEs). So far, the superfamily of PDE is composed of at least 11 isoforms and each family is characterized with unique cellular distribution, expression, regulation mode and inhibitor sensitivity, and PDEs are considered to be involved in a variety of pathological processes, such as inflammation, asthma, depression, and erectile dysfunction, etc. Currently, these characteristics draw PDEs more and more attention as great targets for drugs. In this review, the basic biochemical properties, cellular regulation, expression pattern, physiological functions and inhibitors of different PDE isoforms will be briefly discussed.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalChinese Pharmacological Bulletin
Volume30
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Protein Isoforms
Research
Guanosine Monophosphate
Erectile Dysfunction
Pathologic Processes
Adenosine
Signal Transduction
Hydrolysis
Asthma
Depression
Inflammation
Pharmaceutical Preparations

Keywords

  • cAMP
  • cGMP
  • PDE
  • PDE inhibitors
  • PDE4
  • PDE5

ASJC Scopus subject areas

  • Pharmacology

Cite this

Research progress of phosphodiesterases and phosphodiesterase inhibitors. / Chen, Chang Liang; Huang, Shuang.

In: Chinese Pharmacological Bulletin, Vol. 30, No. 2, 01.01.2014, p. 283-286.

Research output: Contribution to journalReview article

Chen, Chang Liang ; Huang, Shuang. / Research progress of phosphodiesterases and phosphodiesterase inhibitors. In: Chinese Pharmacological Bulletin. 2014 ; Vol. 30, No. 2. pp. 283-286.
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