Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

H. Rheinallt Parri; Caterina M. Hernandez; Kelly T. Dineley

doi:10.1016/j.bcp.2011.06.039

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

H. Rheinallt Parri, Caterina M. Hernandez, Kelly T. Dineley

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the α7 nAChR-Aβ interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.

Original language	English (US)
Pages (from-to)	931-942
Number of pages	12
Journal	Biochemical Pharmacology
Volume	82
Issue number	8
DOIs	https://doi.org/10.1016/j.bcp.2011.06.039
State	Published - Oct 15 2011
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid
Cholinergic
Neuroprotection
Oligomer
Review

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/j.bcp.2011.06.039

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abstract = "Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the α7 nAChR-Aβ interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.",

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Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

Abstract

Keywords

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