Abstract
Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the α7 nAChR-Aβ interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 931-942 |
| Number of pages | 12 |
| Journal | Biochemical Pharmacology |
| Volume | 82 |
| Issue number | 8 |
| DOIs | |
| State | Published - Oct 15 2011 |
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Keywords
- Alzheimer's disease
- Amyloid
- Cholinergic
- Neuroprotection
- Oligomer
- Review
ASJC Scopus subject areas
- Biochemistry
- Pharmacology
Cite this
Research update : Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. / Parri, H. Rheinallt; Hernandez, Caterina M.; Dineley, Kelly T.
In: Biochemical Pharmacology, Vol. 82, No. 8, 15.10.2011, p. 931-942.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Research update
T2 - Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease
AU - Parri, H. Rheinallt
AU - Hernandez, Caterina M.
AU - Dineley, Kelly T.
PY - 2011/10/15
Y1 - 2011/10/15
N2 - Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the α7 nAChR-Aβ interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.
AB - Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the α7 nAChR-Aβ interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.
KW - Alzheimer's disease
KW - Amyloid
KW - Cholinergic
KW - Neuroprotection
KW - Oligomer
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=80052033738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052033738&partnerID=8YFLogxK
U2 - 10.1016/j.bcp.2011.06.039
DO - 10.1016/j.bcp.2011.06.039
M3 - Article
C2 - 21763291
AN - SCOPUS:80052033738
VL - 82
SP - 931
EP - 942
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 8
ER -