Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

Dimitrios Moskofidis, Manuel Battegay, Marie Anne Bruendler, Elisabeth Laine, Ion Gresser, Rolf M. Zinkernagel

Research output: Contribution to journalArticle

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Abstract

The susceptibility to alpha/beta interferon (IFN-α/β) or to gamma interferon (IFN-γ) of various lymphocytic choriomeningitis virus (LCMV) strains was evaluated in C57BL/6 mice and in various cell lines. Anti-IFN-γ treatment in vivo revealed that the LCMV strains Armstrong, Aggressive, and WE were most susceptible to IFN-γ whereas Traub, CI 13-Armstrong, and Docile were resistant. The same pattern of susceptibility to recombinant IFN-γ was observed in vitro. In vivo treatment with anti-IFN-α/β showed a sizeable increase in replication of Aggressive, Armstrong, and WE; effects were less pronounced for Docile, CI 13-Armstrong, or Traub. Correspondingly, WE, Armstrong, and Aggressive were all relatively sensitive to purified IFN- α/β in vitro, and CI 13-Armstrong, Docile, and Traub were more resistant. Overall, there was a good correlation between the capacity of LCMV strains to establish a persistent infection in adult immunocompetent mice and their relative resistance to IFN-γ and IFN-α/β.

Original languageEnglish (US)
Pages (from-to)1951-1955
Number of pages5
JournalJournal of Virology
Volume68
Issue number3
StatePublished - Mar 1 1994
Externally publishedYes

Fingerprint

Lymphocytic choriomeningitis virus
interferon-beta
Interferon-beta
interferon-gamma
Interferon-alpha
Interferon-gamma
mice
Inbred C57BL Mouse
cell lines
Cell Line
Infection
infection
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Moskofidis, D., Battegay, M., Bruendler, M. A., Laine, E., Gresser, I., & Zinkernagel, R. M. (1994). Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon. Journal of Virology, 68(3), 1951-1955.

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon. / Moskofidis, Dimitrios; Battegay, Manuel; Bruendler, Marie Anne; Laine, Elisabeth; Gresser, Ion; Zinkernagel, Rolf M.

In: Journal of Virology, Vol. 68, No. 3, 01.03.1994, p. 1951-1955.

Research output: Contribution to journalArticle

Moskofidis, D, Battegay, M, Bruendler, MA, Laine, E, Gresser, I & Zinkernagel, RM 1994, 'Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon', Journal of Virology, vol. 68, no. 3, pp. 1951-1955.
Moskofidis D, Battegay M, Bruendler MA, Laine E, Gresser I, Zinkernagel RM. Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon. Journal of Virology. 1994 Mar 1;68(3):1951-1955.
Moskofidis, Dimitrios ; Battegay, Manuel ; Bruendler, Marie Anne ; Laine, Elisabeth ; Gresser, Ion ; Zinkernagel, Rolf M. / Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon. In: Journal of Virology. 1994 ; Vol. 68, No. 3. pp. 1951-1955.
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