Abstract
Emergence of resistance to antifungal drugs during therapy for invasive aspergillosis has received scant attention. We recovered Aspergillus isolates from six patients with invasive aspergillosis, who were receiving amphotericin B before fungal isolation. Although isolates were susceptible to amphotericin B in vitro, none of the patients survived. The MIC of amphotericin B for isolates was similar to that for isolates from 35 patients with no prior exposure to amphotericin B. Laboratory attempts to produce amphotericin B resistance in Aspergillus were unsuccessful. These data indicate that emergence of resistance to amphotericin B is uncommon during therapy for invasive aspergillosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 209-213 |
| Number of pages | 5 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 49 |
| Issue number | 1 |
| State | Published - Feb 6 2002 |
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ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Resistance to amphotericin B does not emerge during treatment for invasive aspergillosis. / Moosa, Mahomed Yunus S.; Alangaden, George J.; Manavathu, Elias; Chandrasekar, Pranatharthi H.
In: Journal of Antimicrobial Chemotherapy, Vol. 49, No. 1, 06.02.2002, p. 209-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Resistance to amphotericin B does not emerge during treatment for invasive aspergillosis
AU - Moosa, Mahomed Yunus S.
AU - Alangaden, George J.
AU - Manavathu, Elias
AU - Chandrasekar, Pranatharthi H.
PY - 2002/2/6
Y1 - 2002/2/6
N2 - Emergence of resistance to antifungal drugs during therapy for invasive aspergillosis has received scant attention. We recovered Aspergillus isolates from six patients with invasive aspergillosis, who were receiving amphotericin B before fungal isolation. Although isolates were susceptible to amphotericin B in vitro, none of the patients survived. The MIC of amphotericin B for isolates was similar to that for isolates from 35 patients with no prior exposure to amphotericin B. Laboratory attempts to produce amphotericin B resistance in Aspergillus were unsuccessful. These data indicate that emergence of resistance to amphotericin B is uncommon during therapy for invasive aspergillosis.
AB - Emergence of resistance to antifungal drugs during therapy for invasive aspergillosis has received scant attention. We recovered Aspergillus isolates from six patients with invasive aspergillosis, who were receiving amphotericin B before fungal isolation. Although isolates were susceptible to amphotericin B in vitro, none of the patients survived. The MIC of amphotericin B for isolates was similar to that for isolates from 35 patients with no prior exposure to amphotericin B. Laboratory attempts to produce amphotericin B resistance in Aspergillus were unsuccessful. These data indicate that emergence of resistance to amphotericin B is uncommon during therapy for invasive aspergillosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036156656&partnerID=8YFLogxK
M3 - Article
C2 - 11751792
AN - SCOPUS:0036156656
VL - 49
SP - 209
EP - 213
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 1
ER -