Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet

M. W. Hamrick, C. Pennington, C. N. Webb, C. M. Isales

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Objective: To determine if myostatin deficiency attenuates body fat gain with increased dietary fat intake. Methods: Normal and myostatin-deficient mice were fed control (8-10 kcal %fat) and high-fat (HF) (45 kcal %fat) diets for a period of 8 weeks, starting at 2 months of age. Body composition, including percent body fat, lean mass, and fat mass, were measured using DXA. Serum adipokines were measured using a Beadlyte assay. Results: Two-factor ANOVA revealed significant treatment x genotype interactions for body fat (g), percent body fat, and serum leptin. The HF diet significantly increased body fat, percent body fat, and serum leptin in normal mice but not in myostatin-deficient mice. Conclusion: Loss of myostatin function not only increases muscle mass in animal models but also attenuates the body fat accumulation that usually accompanies an HF diet.

Original languageEnglish (US)
Pages (from-to)868-870
Number of pages3
JournalInternational Journal of Obesity
Issue number5
StatePublished - May 2006


  • Adipocyte
  • GDF-8
  • Leptin
  • Myostatin
  • Resistin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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