Respective role of TNF receptors in the development of experimental cerebral malaria

Rudolf Lucas, Jin Ning Lou, Pierre Juillard, Mark Moore, Horst Bluethmann, Georges E. Grau

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The respective role of the two receptors of TNF in experimental cerebral malaria (CM) was investigated. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2°) were significantly protected from CM, while TNFR1-deficient (Tfnr1°) mice were as susceptible as wild-type mice. The protection of Tnfr2° mice could be explained by their absence of ICAM-1 upregulation and leukocyte sequestration, known to occur in brain microvessels of CM-susceptible animals.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalJournal of Neuroimmunology
Volume72
Issue number2
DOIs
StatePublished - Feb 1 1997
Externally publishedYes

Keywords

  • ICAM-1
  • Plasmodium berghei
  • TNF receptor 2
  • cerebral malaria

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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