Response of pulpal blood flow to intra-arterial infusion of endothelin

Thomas M. Gilbert, David Henry Pashley, Ronald W. Anderson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Laser Doppler flowmetry was used to determine the effect of the vasoconstrictor endothelin 1 (ET-1) on the pulpal blood flow of intact dogs' teeth during mandibular arterial infusion. ET-1 produced a profound decrease in pulpal blood flow of a relatively long duration at lower doses than similar infusions of norepinephrine. The decrease in pulpal blood flow in response to ET-1 was partially attenuated by the calcium channel blocker nifedipine. These findings demonstrate the presence of receptors for ET-1 in the microvasculature of the dental pulp and suggests that ET-1 may function in the local control of the pulpal microcirculation.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalJournal of Endodontics
Volume18
Issue number5
DOIs
StatePublished - Jan 1 1992

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Intra Arterial Infusions
Endothelins
Endothelin-1
Endothelin A Receptors
Dental Pulp
Laser-Doppler Flowmetry
Calcium Channel Blockers
Vasoconstrictor Agents
Nifedipine
Microcirculation
Microvessels
Norepinephrine
Tooth
Dogs

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Response of pulpal blood flow to intra-arterial infusion of endothelin. / Gilbert, Thomas M.; Pashley, David Henry; Anderson, Ronald W.

In: Journal of Endodontics, Vol. 18, No. 5, 01.01.1992, p. 228-231.

Research output: Contribution to journalArticle

Gilbert, Thomas M. ; Pashley, David Henry ; Anderson, Ronald W. / Response of pulpal blood flow to intra-arterial infusion of endothelin. In: Journal of Endodontics. 1992 ; Vol. 18, No. 5. pp. 228-231.
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