Response to comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"

Santhakumar Manicassamy, Bali Pulendran

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin-deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (T H17)/T H1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.

Original languageEnglish (US)
JournalScience
Volume333
Issue number6041
DOIs
StatePublished - Jul 22 2011

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Catenins
Dendritic Cells
Intestines
Immunity
Macrophages
Regulatory T-Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

Response to comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine". / Manicassamy, Santhakumar; Pulendran, Bali.

In: Science, Vol. 333, No. 6041, 22.07.2011.

Research output: Contribution to journalComment/debate

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