TY - JOUR
T1 - Response to comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"
AU - Manicassamy, Santhakumar
AU - Pulendran, Bali
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/7/22
Y1 - 2011/7/22
N2 - Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin-deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (T H17)/T H1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.
AB - Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin-deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (T H17)/T H1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.
UR - http://www.scopus.com/inward/record.url?scp=79960683232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960683232&partnerID=8YFLogxK
U2 - 10.1126/science.1198771
DO - 10.1126/science.1198771
M3 - Comment/debate
AN - SCOPUS:79960683232
VL - 333
SP - 405b
JO - Science
JF - Science
SN - 0036-8075
IS - 6041
ER -