Abstract
Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin-deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (T H17)/T H1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405b |
| Journal | Science |
| Volume | 333 |
| Issue number | 6041 |
| DOIs |
|
| State | Published - Jul 22 2011 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Manicassamy, S., & Pulendran, B. (2011). Response to comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine". Science, 333(6041), 405b. https://doi.org/10.1126/science.1198771