Responses to noxious stimuli in sedated mechanically ventilatedadults

Mary Jo Grap, Cindy L. Munro, Paul A. Wetzel, Jessica M. Ketchum, V. Anne Hamilton, Curtis N. Sessler

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To determine the effect of sedation on physiologic responses and comfort before, during and after a noxious stimulus (endotracheal tube suctioning). Methods: The sample was a subset of a larger, longitudinal descriptive study, blood for endorphins and saliva for alpha-amylase were obtained before and after suctioning. Heart rate (HR), respiration rate (RR), oxygen saturation (SPO2), and arm and leg actigraphy were continuously recorded. Results: 67 subjects from medical and surgical ICUs were primarily deeply (37%) or mildly sedated (54%) prior to suctioning. Alpha-amylase increased post suctioning (p=0.04); endorphins did not change (p=0.58). Neither were modified by sedation. There were no changes in HR, RR or SPO2 post suctioning. Arm (p=0.007) and leg actigraphy (p=0.057) changed from baseline and depended on sedation level (p=0.0005). Conclusions: While a stress marker did increase during suctioning, only the measure of patient arm movement was significantly affected by sedation level.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalHeart and Lung: Journal of Acute and Critical Care
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Actigraphy
Endorphins
Arm
alpha-Amylases
Respiratory Rate
Leg
Heart Rate
Saliva
Longitudinal Studies
Oxygen

Keywords

  • Evaluation
  • Mechanical ventilation
  • Outcomes
  • Sedation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Grap, M. J., Munro, C. L., Wetzel, P. A., Ketchum, J. M., Hamilton, V. A., & Sessler, C. N. (2014). Responses to noxious stimuli in sedated mechanically ventilatedadults. Heart and Lung: Journal of Acute and Critical Care, 43(1), 6-12. https://doi.org/10.1016/j.hrtlng.2013.10.012

Responses to noxious stimuli in sedated mechanically ventilatedadults. / Grap, Mary Jo; Munro, Cindy L.; Wetzel, Paul A.; Ketchum, Jessica M.; Hamilton, V. Anne; Sessler, Curtis N.

In: Heart and Lung: Journal of Acute and Critical Care, Vol. 43, No. 1, 01.01.2014, p. 6-12.

Research output: Contribution to journalArticle

Grap, MJ, Munro, CL, Wetzel, PA, Ketchum, JM, Hamilton, VA & Sessler, CN 2014, 'Responses to noxious stimuli in sedated mechanically ventilatedadults', Heart and Lung: Journal of Acute and Critical Care, vol. 43, no. 1, pp. 6-12. https://doi.org/10.1016/j.hrtlng.2013.10.012
Grap, Mary Jo ; Munro, Cindy L. ; Wetzel, Paul A. ; Ketchum, Jessica M. ; Hamilton, V. Anne ; Sessler, Curtis N. / Responses to noxious stimuli in sedated mechanically ventilatedadults. In: Heart and Lung: Journal of Acute and Critical Care. 2014 ; Vol. 43, No. 1. pp. 6-12.
@article{fc1f925786ea4db78b8a61bdb7188a73,
title = "Responses to noxious stimuli in sedated mechanically ventilatedadults",
abstract = "Objective: To determine the effect of sedation on physiologic responses and comfort before, during and after a noxious stimulus (endotracheal tube suctioning). Methods: The sample was a subset of a larger, longitudinal descriptive study, blood for endorphins and saliva for alpha-amylase were obtained before and after suctioning. Heart rate (HR), respiration rate (RR), oxygen saturation (SPO2), and arm and leg actigraphy were continuously recorded. Results: 67 subjects from medical and surgical ICUs were primarily deeply (37{\%}) or mildly sedated (54{\%}) prior to suctioning. Alpha-amylase increased post suctioning (p=0.04); endorphins did not change (p=0.58). Neither were modified by sedation. There were no changes in HR, RR or SPO2 post suctioning. Arm (p=0.007) and leg actigraphy (p=0.057) changed from baseline and depended on sedation level (p=0.0005). Conclusions: While a stress marker did increase during suctioning, only the measure of patient arm movement was significantly affected by sedation level.",
keywords = "Evaluation, Mechanical ventilation, Outcomes, Sedation",
author = "Grap, {Mary Jo} and Munro, {Cindy L.} and Wetzel, {Paul A.} and Ketchum, {Jessica M.} and Hamilton, {V. Anne} and Sessler, {Curtis N.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.hrtlng.2013.10.012",
language = "English (US)",
volume = "43",
pages = "6--12",
journal = "Heart and Lung: Journal of Acute and Critical Care",
issn = "0147-9563",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Responses to noxious stimuli in sedated mechanically ventilatedadults

AU - Grap, Mary Jo

AU - Munro, Cindy L.

AU - Wetzel, Paul A.

AU - Ketchum, Jessica M.

AU - Hamilton, V. Anne

AU - Sessler, Curtis N.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: To determine the effect of sedation on physiologic responses and comfort before, during and after a noxious stimulus (endotracheal tube suctioning). Methods: The sample was a subset of a larger, longitudinal descriptive study, blood for endorphins and saliva for alpha-amylase were obtained before and after suctioning. Heart rate (HR), respiration rate (RR), oxygen saturation (SPO2), and arm and leg actigraphy were continuously recorded. Results: 67 subjects from medical and surgical ICUs were primarily deeply (37%) or mildly sedated (54%) prior to suctioning. Alpha-amylase increased post suctioning (p=0.04); endorphins did not change (p=0.58). Neither were modified by sedation. There were no changes in HR, RR or SPO2 post suctioning. Arm (p=0.007) and leg actigraphy (p=0.057) changed from baseline and depended on sedation level (p=0.0005). Conclusions: While a stress marker did increase during suctioning, only the measure of patient arm movement was significantly affected by sedation level.

AB - Objective: To determine the effect of sedation on physiologic responses and comfort before, during and after a noxious stimulus (endotracheal tube suctioning). Methods: The sample was a subset of a larger, longitudinal descriptive study, blood for endorphins and saliva for alpha-amylase were obtained before and after suctioning. Heart rate (HR), respiration rate (RR), oxygen saturation (SPO2), and arm and leg actigraphy were continuously recorded. Results: 67 subjects from medical and surgical ICUs were primarily deeply (37%) or mildly sedated (54%) prior to suctioning. Alpha-amylase increased post suctioning (p=0.04); endorphins did not change (p=0.58). Neither were modified by sedation. There were no changes in HR, RR or SPO2 post suctioning. Arm (p=0.007) and leg actigraphy (p=0.057) changed from baseline and depended on sedation level (p=0.0005). Conclusions: While a stress marker did increase during suctioning, only the measure of patient arm movement was significantly affected by sedation level.

KW - Evaluation

KW - Mechanical ventilation

KW - Outcomes

KW - Sedation

UR - http://www.scopus.com/inward/record.url?scp=84891150481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891150481&partnerID=8YFLogxK

U2 - 10.1016/j.hrtlng.2013.10.012

DO - 10.1016/j.hrtlng.2013.10.012

M3 - Article

VL - 43

SP - 6

EP - 12

JO - Heart and Lung: Journal of Acute and Critical Care

JF - Heart and Lung: Journal of Acute and Critical Care

SN - 0147-9563

IS - 1

ER -