Restoration of tolerance in lupus by targeted inhibitory receptor expression

Tracy L. McGaha, Brian Sorrentino, Jeffrey V. Ravetch

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Lupus, a multigenic autoimmune condition in which a breakdown of tolerance results in the development of autoantibodies, leads to a variety of pathologic outcomes. Despite the heterogeneity of factors influencing disease susceptibility, we demonstrate that the partial restoration of inhibitory Fc receptor (FcγRIIB) levels on B cells in lupus-prone mouse strains is sufficient to restore tolerance and prevent autoimmunity. FcγRIIB regulates a common B cell checkpoint in genetically diverse lupus-prone mouse strains, and modest changes in its expression can result in either tolerance or autoimmunity. Therefore, increasing FcγRIIB levels on B cells may be an effective way to treat autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)590-593
Number of pages4
JournalScience
Volume307
Issue number5709
DOIs
StatePublished - Jan 28 2005

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B-Lymphocytes
Autoimmunity
Fc Receptors
Disease Susceptibility
Autoantibodies
Autoimmune Diseases

ASJC Scopus subject areas

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Cite this

Restoration of tolerance in lupus by targeted inhibitory receptor expression. / McGaha, Tracy L.; Sorrentino, Brian; Ravetch, Jeffrey V.

In: Science, Vol. 307, No. 5709, 28.01.2005, p. 590-593.

Research output: Contribution to journalArticle

McGaha, TL, Sorrentino, B & Ravetch, JV 2005, 'Restoration of tolerance in lupus by targeted inhibitory receptor expression', Science, vol. 307, no. 5709, pp. 590-593. https://doi.org/10.1126/science.1105160
McGaha, Tracy L. ; Sorrentino, Brian ; Ravetch, Jeffrey V. / Restoration of tolerance in lupus by targeted inhibitory receptor expression. In: Science. 2005 ; Vol. 307, No. 5709. pp. 590-593.
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