Restoration of tumor suppressor functions by small-molecule inhibitors

Slovénie Pyndiah, Daitoku Sakamuro

Research output: Contribution to journalArticle

Abstract

Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

Original languageEnglish (US)
Article numbere991225
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Keywords

  • BIN1
  • RB1
  • p53
  • small-molecule inhibitor
  • tumor suppressor

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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