Restoration of tumor suppressor functions by small-molecule inhibitors

Slovénie Pyndiah, Daitoku Sakamuro

Research output: Contribution to journalArticle

Abstract

Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

Original languageEnglish (US)
Article numbere991225
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Fingerprint

Tumor Suppressor Proteins
Neoplasms
Therapeutics

Keywords

  • BIN1
  • RB1
  • p53
  • small-molecule inhibitor
  • tumor suppressor

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

Cite this

Restoration of tumor suppressor functions by small-molecule inhibitors. / Pyndiah, Slovénie; Sakamuro, Daitoku.

In: Molecular and Cellular Oncology, Vol. 2, No. 3, e991225, 03.07.2015.

Research output: Contribution to journalArticle

@article{4f06bfca72c74a1d868aa04685ecccc2,
title = "Restoration of tumor suppressor functions by small-molecule inhibitors",
abstract = "Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.",
keywords = "BIN1, RB1, p53, small-molecule inhibitor, tumor suppressor",
author = "Slov{\'e}nie Pyndiah and Daitoku Sakamuro",
year = "2015",
month = "7",
day = "3",
doi = "10.4161/23723556.2014.991225",
language = "English (US)",
volume = "2",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Restoration of tumor suppressor functions by small-molecule inhibitors

AU - Pyndiah, Slovénie

AU - Sakamuro, Daitoku

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

AB - Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.

KW - BIN1

KW - RB1

KW - p53

KW - small-molecule inhibitor

KW - tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=85051767171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051767171&partnerID=8YFLogxK

U2 - 10.4161/23723556.2014.991225

DO - 10.4161/23723556.2014.991225

M3 - Article

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 3

M1 - e991225

ER -