Results of lesional vs. nonlesional frontal lobe epilepsy surgery

J. R. Smith, M. R. Lee, D. W. King, Anthony M Murro, Yong D Park, Gregory P Lee, D. W. Loring, K. J. Meador, R. Harp

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52 Scopus citations

Abstract

Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalStereotactic and Functional Neurosurgery
Volume69
Issue number1-4
DOIs
StatePublished - Dec 1 1997

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Keywords

  • Epilepsy
  • Frontal lobe
  • Invasive localization
  • Long-term outcome
  • Outcome
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Smith, J. R., Lee, M. R., King, D. W., Murro, A. M., Park, Y. D., Lee, G. P., Loring, D. W., Meador, K. J., & Harp, R. (1997). Results of lesional vs. nonlesional frontal lobe epilepsy surgery. Stereotactic and Functional Neurosurgery, 69(1-4), 202-209. https://doi.org/10.1159/000099875