Results of lesional vs. nonlesional frontal lobe epilepsy surgery

J. R. Smith; M. R. Lee; D. W. King; A. M. Murro; Y. D. Park; G. P. Lee; D. W. Loring; K. J. Meador; R. Harp

doi:10.1159/000099875

Results of lesional vs. nonlesional frontal lobe epilepsy surgery

J. R. Smith, M. R. Lee, D. W. King, A. M. Murro, Y. D. Park, G. P. Lee, D. W. Loring, K. J. Meador, R. Harp

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62 Scopus citations

Abstract

Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

Original language	English (US)
Pages (from-to)	202-209
Number of pages	8
Journal	Stereotactic and Functional Neurosurgery
Volume	69
Issue number	1-4
DOIs	https://doi.org/10.1159/000099875
State	Published - 1997

Keywords

Epilepsy
Frontal lobe
Invasive localization
Long-term outcome
Outcome
Surgery

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1159/000099875

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title = "Results of lesional vs. nonlesional frontal lobe epilepsy surgery",

abstract = "Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.",

keywords = "Epilepsy, Frontal lobe, Invasive localization, Long-term outcome, Outcome, Surgery",

author = "Smith, {J. R.} and Lee, {M. R.} and King, {D. W.} and Murro, {A. M.} and Park, {Y. D.} and Lee, {G. P.} and Loring, {D. W.} and Meador, {K. J.} and R. Harp",

year = "1997",

doi = "10.1159/000099875",

language = "English (US)",

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AU - Smith, J. R.

AU - Lee, M. R.

AU - King, D. W.

AU - Murro, A. M.

AU - Park, Y. D.

AU - Lee, G. P.

AU - Loring, D. W.

AU - Meador, K. J.

AU - Harp, R.

PY - 1997

Y1 - 1997

N2 - Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

AB - Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

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KW - Frontal lobe

KW - Invasive localization

KW - Long-term outcome

KW - Outcome

KW - Surgery

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Results of lesional vs. nonlesional frontal lobe epilepsy surgery

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