Results of lesional vs. nonlesional frontal lobe epilepsy surgery

J. R. Smith, M. R. Lee, D. W. King, Anthony M Murro, Yong D Park, Gregory P Lee, D. W. Loring, K. J. Meador, R. Harp

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalStereotactic and Functional Neurosurgery
Volume69
Issue number1-4
DOIs
StatePublished - Dec 1 1997

Fingerprint

Frontal Lobe Epilepsy
Seizures
Stroke
Frontal Lobe

Keywords

  • Epilepsy
  • Frontal lobe
  • Invasive localization
  • Long-term outcome
  • Outcome
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Results of lesional vs. nonlesional frontal lobe epilepsy surgery. / Smith, J. R.; Lee, M. R.; King, D. W.; Murro, Anthony M; Park, Yong D; Lee, Gregory P; Loring, D. W.; Meador, K. J.; Harp, R.

In: Stereotactic and Functional Neurosurgery, Vol. 69, No. 1-4, 01.12.1997, p. 202-209.

Research output: Contribution to journalArticle

Smith, JR, Lee, MR, King, DW, Murro, AM, Park, YD, Lee, GP, Loring, DW, Meador, KJ & Harp, R 1997, 'Results of lesional vs. nonlesional frontal lobe epilepsy surgery', Stereotactic and Functional Neurosurgery, vol. 69, no. 1-4, pp. 202-209. https://doi.org/10.1159/000099875
Smith, J. R. ; Lee, M. R. ; King, D. W. ; Murro, Anthony M ; Park, Yong D ; Lee, Gregory P ; Loring, D. W. ; Meador, K. J. ; Harp, R. / Results of lesional vs. nonlesional frontal lobe epilepsy surgery. In: Stereotactic and Functional Neurosurgery. 1997 ; Vol. 69, No. 1-4. pp. 202-209.
@article{2abc97a6a6294bcda61062fe00cff8c5,
title = "Results of lesional vs. nonlesional frontal lobe epilepsy surgery",
abstract = "Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29{\%}) nonlesional (NL) cases and 21 of 32 (66{\%}) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89{\%}) L cases ≤ 18 years old vs. 13 of 23 (57{\%}) > 18 years old were SF. Eight of 10 (80{\%}) tumor vs. 13 of 22 (59{\%}) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31{\%}) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75{\%}) were SF. Eighteen of 28 (64{\%}) L cases without ictal localization were SF. Nine of 12 (75{\%}) lateral resections, 7 of 12 (58{\%}) lobectomies, and 2 of 13 (15{\%}) mesial resections were SF. Three of 20 cases with at least 90{\%} reduction in seizures became SD ≤ 2 years postresection. No case with <90{\%} seizure reduction at one year showed improvement with longer follow-up.",
keywords = "Epilepsy, Frontal lobe, Invasive localization, Long-term outcome, Outcome, Surgery",
author = "Smith, {J. R.} and Lee, {M. R.} and King, {D. W.} and Murro, {Anthony M} and Park, {Yong D} and Lee, {Gregory P} and Loring, {D. W.} and Meador, {K. J.} and R. Harp",
year = "1997",
month = "12",
day = "1",
doi = "10.1159/000099875",
language = "English (US)",
volume = "69",
pages = "202--209",
journal = "Stereotactic and Functional Neurosurgery",
issn = "1011-6125",
publisher = "S. Karger AG",
number = "1-4",

}

TY - JOUR

T1 - Results of lesional vs. nonlesional frontal lobe epilepsy surgery

AU - Smith, J. R.

AU - Lee, M. R.

AU - King, D. W.

AU - Murro, Anthony M

AU - Park, Yong D

AU - Lee, Gregory P

AU - Loring, D. W.

AU - Meador, K. J.

AU - Harp, R.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

AB - Fifty-three seizure focus resections limited to the frontal lobe were performed. Forty-nine had adequate follow-up. Five of 17 (29%) nonlesional (NL) cases and 21 of 32 (66%) lesional (L) cases were seizure free (SF) at 1 year postoperatively. Eight of 9 (89%) L cases ≤ 18 years old vs. 13 of 23 (57%) > 18 years old were SF. Eight of 10 (80%) tumor vs. 13 of 22 (59%) nontumor L cases were SF. Sixteen NL cases were localized by invasive recording. Five (31%) were SF. Ictal localization was obtained in 4 of 32 L cases. Three of 4 (75%) were SF. Eighteen of 28 (64%) L cases without ictal localization were SF. Nine of 12 (75%) lateral resections, 7 of 12 (58%) lobectomies, and 2 of 13 (15%) mesial resections were SF. Three of 20 cases with at least 90% reduction in seizures became SD ≤ 2 years postresection. No case with <90% seizure reduction at one year showed improvement with longer follow-up.

KW - Epilepsy

KW - Frontal lobe

KW - Invasive localization

KW - Long-term outcome

KW - Outcome

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=0031394038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031394038&partnerID=8YFLogxK

U2 - 10.1159/000099875

DO - 10.1159/000099875

M3 - Article

VL - 69

SP - 202

EP - 209

JO - Stereotactic and Functional Neurosurgery

JF - Stereotactic and Functional Neurosurgery

SN - 1011-6125

IS - 1-4

ER -