Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents

S. Lee Anne Martin, William H. Hoffman, Dennis M. Marcus, Gregory G Passmore, Rory R. Dalton

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalJournal of Diabetes and its Complications
Volume19
Issue number4
DOIs
StatePublished - Jul 1 2005

Fingerprint

Retinal Vessels
Diabetic Ketoacidosis
Blood-Retinal Barrier
Microvessels
Blood-Brain Barrier
Pericytes
Fluorescein Angiography
Diabetic Retinopathy
Retina
Permeability
Therapeutics

Keywords

  • Diabetic ketoacidosis
  • Diabetic retinopathy
  • Retinal imaging

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents. / Martin, S. Lee Anne; Hoffman, William H.; Marcus, Dennis M.; Passmore, Gregory G; Dalton, Rory R.

In: Journal of Diabetes and its Complications, Vol. 19, No. 4, 01.07.2005, p. 233-237.

Research output: Contribution to journalArticle

Martin, S. Lee Anne ; Hoffman, William H. ; Marcus, Dennis M. ; Passmore, Gregory G ; Dalton, Rory R. / Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents. In: Journal of Diabetes and its Complications. 2005 ; Vol. 19, No. 4. pp. 233-237.
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