Abstract
Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 233-237 |
| Number of pages | 5 |
| Journal | Journal of Diabetes and its Complications |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2005 |
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Keywords
- Diabetic ketoacidosis
- Diabetic retinopathy
- Retinal imaging
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents. / Martin, S. Lee Anne; Hoffman, William H.; Marcus, Dennis M.; Passmore, Gregory G; Dalton, Rory R.
In: Journal of Diabetes and its Complications, Vol. 19, No. 4, 01.07.2005, p. 233-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents
AU - Martin, S. Lee Anne
AU - Hoffman, William H.
AU - Marcus, Dennis M.
AU - Passmore, Gregory G
AU - Dalton, Rory R.
PY - 2005/7/1
Y1 - 2005/7/1
N2 - Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.
AB - Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.
KW - Diabetic ketoacidosis
KW - Diabetic retinopathy
KW - Retinal imaging
UR - http://www.scopus.com/inward/record.url?scp=21344431688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21344431688&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2004.08.005
DO - 10.1016/j.jdiacomp.2004.08.005
M3 - Article
VL - 19
SP - 233
EP - 237
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 4
ER -