Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents

S. Lee Anne Martin; William H. Hoffman; Dennis M. Marcus; Gregory G Passmore; Rory R. Dalton

doi:10.1016/j.jdiacomp.2004.08.005

Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents

S. Lee Anne Martin, William H. Hoffman, Dennis M. Marcus, Gregory G Passmore, Rory R. Dalton

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.

Original language	English (US)
Pages (from-to)	233-237
Number of pages	5
Journal	Journal of Diabetes and its Complications
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.jdiacomp.2004.08.005
State	Published - Jul 1 2005

Keywords

Diabetic ketoacidosis
Diabetic retinopathy
Retinal imaging

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents",

abstract = "Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.",

keywords = "Diabetic ketoacidosis, Diabetic retinopathy, Retinal imaging",

author = "Martin, {S. Lee Anne} and Hoffman, {William H.} and Marcus, {Dennis M.} and Passmore, {Gregory G} and Dalton, {Rory R.}",

year = "2005",

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doi = "10.1016/j.jdiacomp.2004.08.005",

language = "English (US)",

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T1 - Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents

AU - Martin, S. Lee Anne

AU - Hoffman, William H.

AU - Marcus, Dennis M.

AU - Passmore, Gregory G

AU - Dalton, Rory R.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.

AB - Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH <7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB.

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