Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages

Santhakumar Manicassamy, Bali Pulendran

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3+ T regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages constitutively express RA synthesizing enzymes, and induce T regulatory cells. In addition, RA programs DCs to imprint mucosal homing properties on activated T and B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalSeminars in Immunology
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

Fingerprint

Tretinoin
Dendritic Cells
Macrophages
B-Lymphocytes
Regulatory T-Lymphocytes
T-Lymphocytes
Biological Phenomena
Vitamin A
Quality Control
Immunoglobulin A
Lymphocytes
Antigens
Enzymes

Keywords

  • Dendritic cells
  • Macrophages
  • Retinoic acid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages. / Manicassamy, Santhakumar; Pulendran, Bali.

In: Seminars in Immunology, Vol. 21, No. 1, 01.02.2009, p. 22-27.

Research output: Contribution to journalReview article

@article{cc0cc4e1be654361b1dfaae9ba97099f,
title = "Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages",
abstract = "Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3+ T regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages constitutively express RA synthesizing enzymes, and induce T regulatory cells. In addition, RA programs DCs to imprint mucosal homing properties on activated T and B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes.",
keywords = "Dendritic cells, Macrophages, Retinoic acid",
author = "Santhakumar Manicassamy and Bali Pulendran",
year = "2009",
month = "2",
day = "1",
doi = "10.1016/j.smim.2008.07.007",
language = "English (US)",
volume = "21",
pages = "22--27",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages

AU - Manicassamy, Santhakumar

AU - Pulendran, Bali

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3+ T regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages constitutively express RA synthesizing enzymes, and induce T regulatory cells. In addition, RA programs DCs to imprint mucosal homing properties on activated T and B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes.

AB - Dendritic cells (DCs) control the strength and quality of antigen-specific T and B cell responses. Recent advances point to a novel mechanism, in which metabolism of vitamin A into retinoic acid (RA) in DCs, regulate critical parameters of lymphocyte differentiation. First, RA enhances the induction of Foxp3+ T regulatory cells by DCs. Thus, specific subsets of intestinal DCs and macrophages constitutively express RA synthesizing enzymes, and induce T regulatory cells. In addition, RA programs DCs to imprint mucosal homing properties on activated T and B cells, and enhanced induction of immunoglobulin-A (IgA) by B cells. Here, we review these recent advances, in the context of the pleiotropic effects of RA in regulating diverse biological processes.

KW - Dendritic cells

KW - Macrophages

KW - Retinoic acid

UR - http://www.scopus.com/inward/record.url?scp=56249130033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56249130033&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2008.07.007

DO - 10.1016/j.smim.2008.07.007

M3 - Review article

VL - 21

SP - 22

EP - 27

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 1

ER -