Retrograde chemoinfusion of the upper tract

standardizing the delivery of topical adjuvant therapy.

Matthew J. Maurice, Rabii Hussein Madi, Debby Y. Chuang, Robert Abouassaly

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Upper tract urothelial carcinoma has a high recurrence rate after endoscopic treatment. Immediate postoperative topical chemotherapy may reduce recurrences, as in bladder cancer. A reliable delivery method to the upper tract does not exist. We propose a new infusion pump technology for the delivery of topical chemotherapeutic agents to the upper tract. With the patient under general anesthesia, contrast is infused into the upper collecting system using a standard infusion pump. An optimal infusion rate is determined based on fluoroscopic filling of the upper collecting system and transduced intrapelvic pressures. Using this rate, the infusion is repeated postoperatively with the chemotherapeutic agent. We report one case of successful execution to demonstrate proof of concept. We are the first to describe retrograde upper tract chemotherapeutic irrigation with an intravenous pump. This technique may facilitate and standardize the delivery of intracavitary chemotherapy. Further investigation to determine whether it translates into improved safety and/or efficacy is warranted.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalJournal of endourology / Endourological Society
Volume27
Issue number5
DOIs
StatePublished - May 1 2013
Externally publishedYes

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Infusion Pumps
Recurrence
Drug Therapy
Urinary Bladder Neoplasms
General Anesthesia
Technology
Carcinoma
Safety
Pressure
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Retrograde chemoinfusion of the upper tract : standardizing the delivery of topical adjuvant therapy. / Maurice, Matthew J.; Madi, Rabii Hussein; Chuang, Debby Y.; Abouassaly, Robert.

In: Journal of endourology / Endourological Society, Vol. 27, No. 5, 01.05.2013, p. 540-544.

Research output: Contribution to journalArticle

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