Retrospective study of intraepidermal nerve fiber distribution in biopsies of patients with nummular eczema

Ben Maddison, Amy Parsons, Omar Sangueza, Daniel J Sheehan, Gil Yosipovitch

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Nummular eczema is a chronic inflammatory condition characterized by pruritus and histologically characterized by spongiosis. The etiology is unknown, and the lesions frequently arise spontaneously. Neuropeptides contribute to mediating and maintaining eczematous conditions. Previous research indicates that the number of immunoreactive nerve fibers is increased in pruritic skin lesions. Objective: We sought to determine if the number of immunoreactive nerve fibers is increased in nummular eczema, as in other inflammatory pruritic conditions. Methods: Protein gene product 9.5 (PGP 9.5) was assessed by immunohistochemistry in 22 biopsies of nummular eczema and was compared with immunohistochemical expression of 8 skin biopsies uninvolved by nummular eczema. Results: Nerve fiber distribution using PGP 9.5 stain showed that there was significantly reduced PGP9.5 stain amount in the epidermis of patients with nummular eczema compared with their respective healthy control (P = 0.0054). However, no statistical difference was seen in the papillary dermis. Conclusion: Pruritus of nummular eczema is not associated with an increase of epidermal nerve fiber density and sprouting.

Original languageEnglish (US)
Pages (from-to)621-623
Number of pages3
JournalAmerican Journal of Dermatopathology
Volume33
Issue number6
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

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Eczema
Nerve Fibers
Retrospective Studies
Biopsy
Pruritus
Coloring Agents
Skin
Dermis
Neuropeptides
Epidermis
Proteins
Immunohistochemistry
Research

Keywords

  • nerve fibers
  • PGP-9.5
  • pruritus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

Retrospective study of intraepidermal nerve fiber distribution in biopsies of patients with nummular eczema. / Maddison, Ben; Parsons, Amy; Sangueza, Omar; Sheehan, Daniel J; Yosipovitch, Gil.

In: American Journal of Dermatopathology, Vol. 33, No. 6, 01.08.2011, p. 621-623.

Research output: Contribution to journalArticle

Maddison, Ben ; Parsons, Amy ; Sangueza, Omar ; Sheehan, Daniel J ; Yosipovitch, Gil. / Retrospective study of intraepidermal nerve fiber distribution in biopsies of patients with nummular eczema. In: American Journal of Dermatopathology. 2011 ; Vol. 33, No. 6. pp. 621-623.
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