Reversal of compromised bonding to oxidized etched dentin

S. C.N. Lai, Y. F. Mak, G. S.P. Cheung, R. Osorio, M. Toledano, R. M. Carvalho, F. R. Tay, D. H. Pashley

Research output: Contribution to journalArticlepeer-review

236 Scopus citations


The mechanism responsible for hydrogenperoxide- or sodium-hypochlorite-induced reductions in dentin bond strength is unknown. This in vitro study tested the hypothesis that these oxidizing agents were responsible by attempting to reverse the effect with sodium ascorbate, a reducing agent. Human dentin was treated with these oxidants before or after being acid-etched and with or without post-treatment with sodium ascorbate. They were bonded with either Single Bond or Excite. Hydrogen peroxide reduced the bond strengths of both adhesives, while sodium hypochlorite produced reduction in adhesion of only Single Bond (p < 0.05). Following treatment with sodium ascorbate, reductions in bond strength were reversed. Transmission and scanning electron microscopy showed partial removal of the demineralized collagen matrix only by sodium hypochlorite. The observed compromised bond strengths cannot be attributed to incomplete deproteinization and may be related to changes in the redox potential of the bonding substrates.

Original languageEnglish (US)
Pages (from-to)1919-1924
Number of pages6
JournalJournal of Dental Research
Issue number10
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Dentistry(all)


Dive into the research topics of 'Reversal of compromised bonding to oxidized etched dentin'. Together they form a unique fingerprint.

Cite this