Reversal of effects of morphine by nalmefene

R. Nagarajan, S. Jeyashree, M. Shanmugam, V. Bala Subramanian, R. R. Tuttle, Robert William Caldwell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The safety and efficacy of a new potent longlasting opioid antagonist, nalmefene (6-desoxy-6-methylene-naltrexone), were evaluated in this open label study. The ability of malmefene to reverse the effects of morphine in 30 women who underwent voluntary tubal ligation with 0.2-0.5 mg/kg of morphine, i.m., as premedication was determined. Efficacy of nalmefene was assessed by measuring alertness (reversal of narcosis) and increase in pain (reversal of analgesia). Both measures of efficacy were significantly increased within 30 minutes of nalmefene administration (p < 0.05). Heart rate, respiratory rate, and blood pressure were not affected, suggesting acceptable tolerance.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalJournal of Clinical Research and Drug Development
Volume7
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Morphine
Stupor
Tubal Sterilization
Naltrexone
Aptitude
Narcotic Antagonists
Premedication
Respiratory Rate
Analgesia
Heart Rate
Blood Pressure
Safety
Pain
nalmefene

Keywords

  • Analgesia
  • Nalmefene
  • Narcosis
  • Opioid antagonist
  • Tubal ligation

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology (medical)

Cite this

Nagarajan, R., Jeyashree, S., Shanmugam, M., Bala Subramanian, V., Tuttle, R. R., & Caldwell, R. W. (1993). Reversal of effects of morphine by nalmefene. Journal of Clinical Research and Drug Development, 7(1), 25-29.

Reversal of effects of morphine by nalmefene. / Nagarajan, R.; Jeyashree, S.; Shanmugam, M.; Bala Subramanian, V.; Tuttle, R. R.; Caldwell, Robert William.

In: Journal of Clinical Research and Drug Development, Vol. 7, No. 1, 01.01.1993, p. 25-29.

Research output: Contribution to journalArticle

Nagarajan, R, Jeyashree, S, Shanmugam, M, Bala Subramanian, V, Tuttle, RR & Caldwell, RW 1993, 'Reversal of effects of morphine by nalmefene', Journal of Clinical Research and Drug Development, vol. 7, no. 1, pp. 25-29.
Nagarajan R, Jeyashree S, Shanmugam M, Bala Subramanian V, Tuttle RR, Caldwell RW. Reversal of effects of morphine by nalmefene. Journal of Clinical Research and Drug Development. 1993 Jan 1;7(1):25-29.
Nagarajan, R. ; Jeyashree, S. ; Shanmugam, M. ; Bala Subramanian, V. ; Tuttle, R. R. ; Caldwell, Robert William. / Reversal of effects of morphine by nalmefene. In: Journal of Clinical Research and Drug Development. 1993 ; Vol. 7, No. 1. pp. 25-29.
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