Review article: Diagnosis and management of night-time reflux

J. E. McGuigan, P. C. Belafsky, L. Fromer, D. McCarthy, T. Nostrant, G. N. Postma, L. S. Welage, M. M. Wolfe

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Symptoms of gastro-oesophageal reflux disease (GERD) range from mild to severe and, when they occur during night-time hours, can interfere with sleep patterns and reduce overall quality of life. The clinical presentation of GERD is characterized by oesophageal as well as supraoesophageal symptoms, including otolaryngologic and pulmonary complications. However, GERD may be overlooked as the cause of a patient's supra-oesophageal symptoms because these complaints can occur in the absence of oesophageal symptoms or endoscopic changes. The role of available tools used for GERD diagnosis, including endoscopy, oesophageal pH monitoring and an empirical course of proton pump inhibitor therapy, is discussed. Interventions available to achieve the therapeutic goals of symptom relief and prevention include specific lifestyle modifications and over-the-counter as well as prescription pharmacological agents. Patient-initiated, as-needed treatment may not be the best choice for managing persistent night-time reflux because it requires patient arousal from sleep. Proton pump inhibitor therapy remains the treatment of choice for patients with more severe symptoms and those with erosive oesophagitis. Few studies have specifically evaluated the role of pharmacological agents in the management of night-time reflux and comparisons are difficult due to the variability in study design and endpoints assessed.

Original languageEnglish (US)
Pages (from-to)57-72
Number of pages16
JournalAlimentary Pharmacology and Therapeutics, Supplement
Volume20
Issue number9
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Time Management
Esophageal Diseases
Gastroesophageal Reflux
Proton Pump Inhibitors
Sleep
Pharmacology
Esophageal pH Monitoring
Therapeutics
Esophagitis
Arousal
Endoscopy
Prescriptions
Life Style
Quality of Life
Lung

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

McGuigan, J. E., Belafsky, P. C., Fromer, L., McCarthy, D., Nostrant, T., Postma, G. N., ... Wolfe, M. M. (2004). Review article: Diagnosis and management of night-time reflux. Alimentary Pharmacology and Therapeutics, Supplement, 20(9), 57-72.

Review article : Diagnosis and management of night-time reflux. / McGuigan, J. E.; Belafsky, P. C.; Fromer, L.; McCarthy, D.; Nostrant, T.; Postma, G. N.; Welage, L. S.; Wolfe, M. M.

In: Alimentary Pharmacology and Therapeutics, Supplement, Vol. 20, No. 9, 01.12.2004, p. 57-72.

Research output: Contribution to journalReview article

McGuigan, JE, Belafsky, PC, Fromer, L, McCarthy, D, Nostrant, T, Postma, GN, Welage, LS & Wolfe, MM 2004, 'Review article: Diagnosis and management of night-time reflux', Alimentary Pharmacology and Therapeutics, Supplement, vol. 20, no. 9, pp. 57-72.
McGuigan JE, Belafsky PC, Fromer L, McCarthy D, Nostrant T, Postma GN et al. Review article: Diagnosis and management of night-time reflux. Alimentary Pharmacology and Therapeutics, Supplement. 2004 Dec 1;20(9):57-72.
McGuigan, J. E. ; Belafsky, P. C. ; Fromer, L. ; McCarthy, D. ; Nostrant, T. ; Postma, G. N. ; Welage, L. S. ; Wolfe, M. M. / Review article : Diagnosis and management of night-time reflux. In: Alimentary Pharmacology and Therapeutics, Supplement. 2004 ; Vol. 20, No. 9. pp. 57-72.
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